Albuquerque begun his professional career working in advertising, doing work for local companies. He began his comic book career in 2002, after posting his portfolio on the Internet, doing work for the Egyptian publishing company
AK Comics, In 2005, Albuquerque published the
creator-owned graphic novel crime story
Rumble in La Rambla. It would be published in the United States in 2007 by
Image Comics under the title
Crimeland. He collaborated with writers
Keith Giffen and
Alan Grant in 2006 by illustrating issues #4 and #5 of
Jeremiah Harm and the first issue of
Pirate Tales for
Boom! Studios. In 2006 and 2007, he illustrated the mini series
Savage Brothers, also for Boom! Studios. Albuquerque first gained the notice of U.S. comics readers with his work as the regular
artist on the
DC Comics monthly series
Blue Beetle, That same year, Albuquerque illustrated writer
Ivan Brandon's story, "Wild Goose", which appeared in the
Dark Horse Comics anthology
Tales of the Fear Agent. In 2009 he drew issues #3 and #4 of
Strange Adventures and drew the covers to
Marvel Comics' four-issue miniseries
Nomad: Girl Without a World. In January 2010,
Newsarama named Albuquerque one of ten creators to watch for the coming year. Albuquerque, with Eduardo Medeiros and Mateus Santolouco, wrote
Mondo Urbano, a graphic novel published by
Oni Press. That same year Albuquerque began illustrating
American Vampire, a horror series published by DC Comics'
Vertigo imprint, the first five issues of which consisted of two separate stories, one by
Scott Snyder and one by
Stephen King, marking King's first original work for comics. Albuquerque illustrated the two stories with different styles, representative of both the personalities of the characters and the eras in which they were set, explaining that he utilized high-contrast blacks and whites for the 1920s story featuring Pearl in order to evoke the films of that era, and a "dirtier, sketchier technique" involving traditional inking,
ink wash and pencils for the 1880s story featuring bank robber Skinner, in order to evoke that story's "rough and violent" setting. The first hardcover collection appeared on
The New York Times Best Seller list, and the series won
IGN's Best of 2010 Award, 2011
Eisner Award and the 2011
Harvey Award, all of them for Best New Series. In 2012 Albuquerque illustrated and wrote his first story for DC Comics, which appeared in
Legends of the Dark Knight. He drew backup stories for
Batman vol. 2 #21–23 (August–October 2013) as part of the "
Batman: Zero Year" storyline. Albuquerque publishes a creator-owned
webcomic in Brazil titled
Tune 8, which follows a time traveler named Joshua who has only a disembodied female voice as to guide him through the foreign and inhospitable place in which he finds himself.
Tune 8 was serialized on the Brazilian website IG.com.br, and later became the 5-part mini series
Eight, published by Dark Horse Comics. In 2013, he co-scripted with frequent collaborator Scott Snyder the 64-page
American Vampire one-shot
The Long Road to Hell. ==Personal life==