After completing her studies in Leningrad, Berg moved to Moscow to work at the A. N. Severtsov Institute of Evolutionary Morphology under
I. I. Schmalhausen. The institute was evacuated to
Kazakhstan in 1941, but the following year Berg returned to Moscow to work on her doctoral dissertation. From 1944 to 1947 she worked as a senior researcher at the Severtsov Institute and part-time at the Zoological Institute of
Moscow University.
Lysenkoism pressured Soviet geneticists, pushing many researchers out of their institutions. By the time of Berg's dismissal from Moscow University, "there was only one geneticist at Moscow University's Department of Darwinism and one geneticist at the Institute of Evolutionary Morphology, and I was both of them." Berg continued botanical experiments to support her doctoral dissertation and published work relating to her father's expeditions. In 1948, Berg began work as an associate professor of the
Herzen Leningrad Pedagogical Institute, and in 1949 moved to the All-Union Research Institute of Lake and River Fish Management. She then worked at
Leningrad State University; between 1954 and 1963 she was an assistant, then associate professor, and finally senior research associate. From 1964 to 1968, Berg headed the Laboratory of Population Genetics of the Institute of Cytology and Genetics and worked as a lecturer at
Novosibirsk State University. After being forced out of Novosibirsk in 1968, Berg returned to Leningrad. She headed a group at the
Agrophysical Institute of VASKhNIL from 1968 to 1970 and was a professor at
Herzen Leningrad Pedagogical University from 1968 to 1974. In the mid-1970s, Berg emigrated to the United States. She held a position at the
University of Wisconsin–Madison from 1975 to 1981, and from 1984 to 1984 was a visiting professor at
Washington University in St. Louis. She traveled and lectured extensively before relocating to France in 1994. ==Political opinions==