After his formal education ended, Soyer became associated with the Fourteenth Street School of painters that included
Reginald Marsh,
Isabel Bishop,
Kenneth Hayes Miller,
Peggy Bacon and, his teacher,
Guy Pene du Bois. Soyer persistently investigated a number of themes—female nudes, portraits of friends and family, New York and, especially, its people—in his paintings, drawings, watercolors and prints. He also painted a vast number of self-portraits throughout his career. Soyer was adamant in his belief in
representational art and strongly opposed the dominant force of
abstract art during the late 1940s and early 1950s. After his time in art school, Soyer did not immediately begin working as a professional artist, and instead painted during his free time while working other jobs. Soyer's first solo exhibition took place in 1929. Beginning in the early 1930s, he showed regularly in the large annual and biennial American exhibitions of the
Whitney Museum of American Art, the
Carnegie Institute, the
Art Institute of Chicago, the
Corcoran Gallery of Art, the
National Academy of Design, and the
Pennsylvania Academy of the Fine Arts. He was also a member of the
Society of American Graphic Artists. Soyer's teaching career began at the
John Reed Club, New York, in 1930 and included stints at the
Art Students League, the
New School for Social Research and the National Academy. He was an artist of the
Great Depression, and during the 1930s, Raphael and his brother Moses engaged in Social Realism, demonstrating empathy with the struggles of the working class. In 1939, the twins worked together with the
Works Project Administration,
Federal Art Project (WPA-FAP) mural at the
Kingsessing Station post office in
Philadelphia. Soyer deeply admired fellow American artist Thomas Eakins, and produced a group portrait entitled
Homage to Thomas Eakins, which was based on
Fantin-Latour's
Hommage à Delacroix. Among Soyer's portrait subjects were artists and writers who were his friends; these included
Allen Ginsberg,
Arshile Gorky,
Chaim Gross,
Gitel Steed,
Edward Hopper,
Philip Evergood,
Alice Neel and
Steve Poleskie. In 1967 the
Whitney Museum of American Art exhibited a retrospective of his work. He also illustrated two books for
Isaac Bashevis Singer, entitled
A Little Boy in Search of God and
Love and Exile. == Awards and honors ==