After his playing career, Renteria has remained in baseball. His first minor league managerial job was in with the
Brevard County Manatees in the Marlins organization. He continued to manage in the Marlins system until . In , he was named the hitting coach for the
Lake Elsinore Storm in the Padres organization, and in he became the Storm's manager. After three seasons with the Storm, in he was moved up to the Triple-A
Portland Beavers. He was promoted to a major league coaching job in . Renteria moved to being the Padres bench coach for 2011. He also managed the
Mexico national baseball team in the
2013 World Baseball Classic. On November 7, 2013, Renteria was hired as the manager of the
Chicago Cubs. After one season on the job, he was terminated on October 31, 2014, one week after his Cubs successor
Joe Maddon opted out of his contract with the
Tampa Bay Rays. For the 2016 season, Renteria was hired by the Chicago White Sox to serve as their bench coach. Renteria was the second manager in Chicago baseball history, after
Johnny Evers, to manage both the city's franchises. In 2017, he was ejected seven times, more than any other manager in the major leagues. In 2020, he took the White Sox to the playoffs for the first time since
2008. They went off to a 18-12 midway point in the COVID-affected season of 60 games; despite being in the lead for the division, they would fade down the stretch, which included losing eight of their last ten games. A 2-8 record against Cleveland meant that not only did they finish a game behind Minnesota for the division, it also meant that the White Sox finished in third place and thus were relegated to the first wild card spot. They played in the
Wild Card Series against the AL West champion
Oakland Athletics. The White Sox won Game 1 but failed to win either of the next two and were thus eliminated. On October 12, the White Sox announced that Renteria would not return as manager, ending his tenure with the team with one year remaining on his contract. His overall record in four seasons with the Sox was 236-309. ==Managerial record==