Film Carradine made his film debut in 1972 in
The Cowboys, starring
John Wayne. He also appeared in a short‑lived television series of the same name based on the film. He later played a killer in
Martin Scorsese's
Mean Streets, shooting the character portrayed by his brother David. During this period, he worked with David on several independent projects, including the biker film
You and Me (1975) and an unreleased musical titled
A Country Mile. He also handled camera work for David's
Vietnam War-inspired cult film
Americana, which was not released until 1983. Carradine joined other Hollywood offspring in the 1977 film
Joyride, starring alongside
Desi Arnaz, Jr.,
Melanie Griffith, and
Anne Lockhart in a story about young Californians traveling to Washington and Alaska to seek their fortunes. In 1978, he landed a role in
Hal Ashby's Oscar-winning Vietnam War drama
Coming Home, starring
Jane Fonda and
Jon Voight. His performance prompted speculation that he might be the strongest actor in the Carradine family. Also in 1980, he co-starred with
Mark Hamill and
Lee Marvin in
Samuel Fuller's
The Big Red One, a
World War II drama based on Fuller's own experiences. Carradine's character, modeled on Fuller, narrates the film. In 1983, he starred opposite
Cherie Currie of
the Runaways in the science fiction film
Wavelength, playing a washed‑up rock musician who helps extraterrestrials escape from a military base. He performed several of his own compositions for the film, including one named after his daughter Ever. That same year, he appeared as the love interest in
the Motels' music video for the hit song "
Suddenly Last Summer." Carradine achieved his greatest commercial success in 1984 when he starred as Lewis Skolnick in
Revenge of the Nerds. To prepare for the role, he spent time at the
University of Arizona during rush week; no fraternity selected him, reinforcing his sense that he was right for the part. He reprised the role in three sequels, serving as executive producer on the latter two. In 2001, he played Donald Keeble in ''
Max Keeble's Big Move. In 2000, he co-starred with Caroline Rhea in Mom's Got a Date with a Vampire and he reprised his role as Sam McGuire in The Lizzie McGuire Movie'' in 2003.
Television Carradine's first television appearance came in 1971 on the Western series
Bonanza. He later appeared on his brother David's series
Kung Fu as Sunny Jim, the mute companion of Serenity Johnson, played by their father, John Carradine, in the 1972 episode "Dark Angel". In 1979, he appeared alongside
Melissa Sue Anderson in
The Survival of Dana. He also appeared in the 1987
HBO miniseries
Conspiracy: The Trial of the Chicago 8. Carradine guest-starred in the
Law & Order: Criminal Intent episode "Gone" (2005), playing a character loosely based on
Bobby Fischer, and appeared in the television series
Jane Doe, directed by
James A. Contner, in 2007. From 2001 to 2004, Carradine played father Sam McGuire on
Lizzie McGuire, starring
Hilary Duff. The series was widely popular among young viewers, and its realistic portrayal of adolescent issues also appealed to parents. He later appeared in the
ER episode "Sleepless in Chicago" alongside his
Revenge of the Nerds co-star
Anthony Edwards. In January 2013, Carradine reunited with
Revenge of the Nerds co-star
Curtis Armstrong to host
King of the Nerds on
TBS, a reality competition series. In 2015, he appeared on a fourth-season episode of
Celebrity Wife Swap with
Hall of Fame wide receiver
Terrell Owens. ==Personal life and death==