Lord Sempill is a title in the Peerage of Scotland. It was created in circa 1489 for Sir John Sempill, founder of the collegiate Church of Lochwinnoch. Sempill was killed at the Battle of Flodden in 1513. His grandson, the third Lord, was known as "The Great Lord Sempill". His grandson, the fourth Lord, was Ambassador from King James VI of Scotland to Spain in 1596. The male line failed on the death of his great-grandson, the eighth Lord, in 1684. He was succeeded by his sister Anne, wife of Robert Abercromby, who in 1685 was created Lord Glassford for life. In 1688 she obtained a new charter settling the lordship of Sempill in default of male issue, upon her daughters without division by her then and any future husband. Her younger son, the twelfth Lord, commanded the left wing of the government army at the Battle of Culloden in 1746.