The book centers on Rosemary Woodhouse, a young woman who moves into the Bramford, a historic
Gothic Revival-style New York City apartment building, with her husband, Guy, a struggling actor. Guy has so far appeared only in small roles in the stage plays
Luther, Nobody Loves an Albatross, and various TV commercials. A friend warns the pair that the Bramford has a disturbing history involving
witchcraft and murder, but they discount this. Rosemary wants to start a family, but Guy prefers waiting until his career is more established. Neighbors Minnie and Roman Castevet, an eccentric, elderly couple, welcome Rosemary and Guy to the Bramford. Rosemary finds them meddlesome and annoying, but Guy begins frequently visiting them. After the lead actor in a new stage play suddenly goes blind, Guy is cast in the role. Immediately afterward, Guy unexpectedly agrees with Rosemary that they should have their first child. That night, Rosemary dreams of a rough sexual encounter with a huge, inhuman creature with yellow eyes. The next morning Rosemary finds claw marks on her breasts and groin, which Guy dismisses as resulting from his
hangnail, which he has cut. Rosemary subsequently learns that she is pregnant. Rosemary falls severely ill; but her intense pain and weight loss are ignored by others and attributed to
hysteria. Her doctor and Minnie feed her strange and foul concoctions. Rosemary also develops a peculiar craving for
raw meat. Guy's performance in the play garners favorable notices, and other increasingly significant roles follow. Guy soon begins talking about a career in
Hollywood. Rosemary's friend, Edward "Hutch" Hutchins, also becomes mysteriously ill. He had sent Rosemary a warning, leading to her discovery that Roman Castevet is the leader of a
Satanic coven. She suspects her unborn baby is wanted as a sacrifice to the
devil. Despite her growing conviction, she is unable to convince anyone, particularly Guy. Ultimately, Rosemary discovers the coven's real intent for wanting her baby, whom she names Andrew. == Publication ==