In 1995 Penry-Jones appeared with his mother on television in
Cold Comfort Farm. Penry-Jones made his London stage debut at the
Hackney Empire theatre in 1995 playing Fortinbras to
Ralph Fiennes's Hamlet in an
Almeida production of
Hamlet. He was cast as Richard in the premiere staging of
Stephen Poliakoff's
Sweet Panic at
Hampstead Theatre in 1996. In 1998 he created the role of the Boy in
Edward Albee's
The Play About the Baby at the
Almeida Theatre. in 2001 he was cast as Robert Caplan in
J.B. Priestley's thriller "time-play"
Dangerous Corner opposite
Dervla Kirwan, who played Olwen Peel at the
West Yorkshire Playhouse,
Leeds. He also went on to play the role of Captain Wentworth in ITV's adaptation of
Persuasion. A second series of the show based around the
Kray twins was broadcast in autumn 2010; the third series began in January 2012. The fourth and last series aired in September 2013. From 2012 to 2014 Penry-Jones was also cast opposite
Maxine Peake in a legal drama
Silk created by
Peter Moffat. The show revolves around two barristers, played by Penry-Jones and Peake who are competing to become
QCs. Series 2 aired in 2012 and Series 3 premiered on 24 February 2014. He also joined the cast of the film
A Little Chaos with
Kate Winslet as Antoine. The film was directed by
Alan Rickman. From 2014 to 2017 he joined the cast of
Guillermo del Toro's
The Strain, playing a main role as Mr.Quinlan, a vampire-human hybrid (on the side of humans), intent on killing his father... The Master. Playing Mr.Quinlan involved wearing prosthetics and a lot of make-up, for 29 episodes over 3 seasons, something Penry-Jones admitted he would not consider again in television. later reported to be that of Gotham City Mayor Don Mitchell, Jr. In 2022 Penry-Jones starred as Mike/Toby in ITV 1's drama
Our House alongside
Martin Compston and
Tuppence Middleton. == Personal life ==