Main cast •
Corey Stoll as Dr. Ephraim "Eph" Goodweather, the head of the
CDC Canary Team in New York City. •
Mía Maestro as Dr. Nora Martinez, a member of the CDC Canary Team and Eph's closest ally (seasons 1–2). •
Kevin Durand as Vasiliy Fet, a once-solitary rat exterminator of
Ukrainian descent, who is caught up in the fight for humanity. •
Jonathan Hyde as Eldritch Palmer/The Master, an elderly, disabled billionaire driven to obtain immortality. Charlie Gallant portrays a young Palmer in flashbacks. •
Sean Astin as Jim Kent, a CDC administrator who works with Eph and Nora (season 1, guest season 2). •
Jack Kesy as Gabriel Bolivar/The Master, a philandering rock star with an appetite for recreational drugs and is one of the Master's vampire acolytes before becoming the Master's host body (seasons 1–2, recurring season 3). •
Natalie Brown as Kelly Goodweather, Eph's estranged wife (seasons 1–3, recurring season 4). •
Miguel Gomez as Augustin "Gus" Elizalde, a gang member who just got out of juvenile prison. • Ben Hyland (season 1) and
Max Charles (seasons 2–4) as Zach Goodweather, the son of Ephraim and Kelly. •
Robin Atkin Downes as the voice of the Master, one of the seven Ancient vampires and the series' central antagonist. •
Ruta Gedmintas as Dutch Velders, an internet hacker hired by Palmer, who turns against the company when she realizes what she has done (recurring season 1, main seasons 2–4). •
Rupert Penry-Jones as Mr. Quinlan, a half-vampire with a vendetta against the Master (seasons 2–4). •
Samantha Mathis as Justine Feraldo, a tenacious New York City councilwoman for
Staten Island (recurring season 2, main season 3). •
Joaquín Cosío as Angel Guzman Hurtado, a retired wrestler once known as "The Silver Angel" (recurring season 2, main season 3).
Recurring cast •
Cas Anvar as Sanjay Desai, a Stoneheart employee and subordinate of Eichhorst (seasons 3–4). •
Pedro Miguel Arce as Felix, Gus's friend (season 1). •
Adriana Barraza as Guadalupe Elizalde, Gus and Crispin's mother (seasons 1–3). •
Brenda Bazinet as Pauline McGeever, a vampire victim experimented on by Eph and Nora (season 2). •
Nigel Bennett as Dr. Werner Dreverhaven, a former Nazi physician turned vampire (seasons 2–3). • Anne Betancourt as Mariela Martinez, Nora's mother who has
dementia (season 1). •
Lizzie Brocheré as Coco Marchand, Palmer's new personal assistant (season 2). •
Inga Cadranel as Diane, a
Queens native and Kelly's best friend (season 1). •
Ron Canada as George Lyle, the
Mayor of New York City (season 2). •
Francis Capra as Crispin Elizalde, Gus's con artist brother (season 1). • Miranda Edwards as Eve, a human agent working with Quinlan and The Ancients (season 2). •
Kevin Hanchard as Curtis Fitzwilliam, a firefighter and Reggie's brother (season 2). •
Jamie Hector as Alonso Creem, an arms dealer and gang leader (seasons 1–2, 4). •
Leslie Hope as Joan Luss, an attorney and one of the plane's surviving passengers (season 1). •
Jocelyn Hudon as Abby, a maid who befriends Zach (season 4). •
Doug Jones as one of the Ancients, the seven original vampires. Jones also portrays the Master's previous host before Jusef in a flashback (seasons 1–3). •
Daniel Kash as Dr. Everett Barnes, the director of the
CDC and later
Secretary for Health and Human Services (seasons 1–2). •
Parveen Kaur as Aanya Gupta, a waitress and the daughter of the owners of the Tandoori Palace (season 2). • Tom Kemp as Cardinal McNamara, a
Catholic cardinal who is selling an item of interest to both Setrakian and Palmer (season 2). •
Regina King as Ruby Wain, Bolivar's intelligent and accomplished manager (season 1). •
Ron Lea as Harrison McGeever, a vampire victim experimented on by Eph and Nora (season 2). •
Robert Maillet as Jusef Sardu, a 19th-century
Polish noble who was the Master's host body until he was gravely injured (seasons 1–2, 4). •
Stephen McHattie as Vaun, leader of a band of undead hunters sent to destroy the vampire outbreak (seasons 1–2). •
Melanie Merkosky as Sylvia Kent, Jim Kent's cancer-stricken wife (season 1). • Paulino Nunes as Captain Frank Kowalski, an
NYPD officer working with Justine Feraldo (season 2–3). •
America Olivo as Captain Kate Rogers, the commander of a squad of NYPD combatants (season 3). •
Angel Parker as Alex Green, the leader of a group of anti-strigoi resistance fighters (season 4). • Jonathan Potts as Captain Doyle Redfern, pilot of the flight and one of the outbreak's few survivors (season 1). •
Michael Reventar as Raul, Gus's cousin (season 4). •
Kim Roberts as Neeva, Joan Luss' nanny and housekeeper (season 1). • Nikolai Witschl as Ansel Barbour, one of the plane's surviving passengers (season 1). •
Alex Paxton-Beesley as Ann-Marie Barbour wife of Ansel Barbour (season 1). == Production ==