Main •
Evan Peters as Cooper Madsen, a former Navy SEAL and FBI agent investigating deaths linked to "the Beauty" • Hudson Barry as Cooper after the transformation •
Anthony Ramos as Antonio / the Assassin, an enforcer working for "the Corporation" who took it three years ago to keep himself from aging •
Vincent D'Onofrio as Byron before the transformation
Recurring •
Isabella Rossellini as Franny Forst, Byron's estranged wife •
Nicola Peltz Beckham as Franny after the transformation •
John Carroll Lynch as FBI Supervisor Meyer Williams •
Patrick Luwis as Meyer after the transformation •
Rob Yang as Dr. Ray Lee, a scientist and the original developer of the "Beauty" drug who now works for Byron •
Ari Graynor as Dr. Diana Sterling, a roboticist and the creator of the "Deacons"
Guest •
Bella Hadid as Ruby Rossdale, a supermodel who combusted from the "Beauty"'s side effects after rampaging in Paris •
Jon Jon Briones as Dr. Dilegre, a plastic surgeon who works at ANUU • Céline Menville as Vincent Seraphine • Chanel Stewart as Claire, a mysterious woman who infected Jeremy •
Joey Pollari as Mike McGuinn, a scientist and Ray's colleague •
Eddie Kaye Thomas as Mike before the transformation •
Ben Platt as Manny, a Condé Nast employee who is infected by Harper after her combustion •
Isaac Powell as Manny after the transformation •
Meghan Trainor as Brittany, a Condé Nast employee •
Amelia Gray Hamlin as Harper Rose, an assistant editor for
Vogue who infected numerous Condé Nast employees during her combustion •
Gus Halper as Ashley Sanders, a Condé Nast employee and survivor of Harper's rampage •
T. Ryder Smith as Dr. Terry •
Peter Gallagher as Axel Zufo, a fossil fuels billionaire •
Billy Eichner as Waylen Lemming, a crypto billionaire •
David Pittu as Ronan Wylde, a banking billionaire •
Julie Halston as Kitty Munson, a multinational retail billionaire • Matthew Laureano as Nate, a victim who is tortured and killed by the Assassin and Jeremy • Rev Yolanda as Clara Gardner, a transgender scientist and Mike's best friend •
Lux Pascal as Clara after the transformation •
Laura Dreyfuss as Jennifer King • Robert Harrington as Jefferson, Byron's bodyguard •
Kelli O'Hara as Juliana Williams, Meyer's wife • Hazel Graye as Juliana after the transformation • Kaylee Halko as Joey, the teenage daughter of Meyer and Juliana who has
progeria • Augusta Liv as Joey after the transformation •
Kevin Cahoon as Tiger "Tig" Forst, one of Byron and Franny's sons •
Ray Nicholson as Tig after the transformation •
Eric Petersen as Gunther Forst, one of Byron and Franny's sons • Brandon Gillard as Gunther after the transformation •
Anthony Rapp as a Scientist who worked for the space colonization division of Byron's corporation • Emma Halleen as Bella Grant, a school student who becomes fixated on the "Beauty" • Annabelle Wachtel as Ruthie, Bella's best friend who is lamenting a failed
nose job • Paige McGarvin as Ruthie after the transformation •
Maria Dizzia as Bella's mother • Daniel Stewart Sherman as Bella's father • Carson Rowland as Conor, an employee of Byron's corporation who administers doses of the "Beauty" • Ethan Eisenstein as Conor before the transformation • Red Concepcion as Sir Ma'am, a social media influencer • Sky Kawai as Sir Ma'am after the transformation ==Episodes==