;Main cast •
Piolo Pascual as
Vice President Rafael Sagrado / Gabriel •
Kyle Echarri as Moises "Moi" M. Sagrado / Sebastian / Baste •
Grae Fernandez as
Second Son Justin R. Sagrado •
Tirso Cruz III as Justice Secretary Jaime Sagrado •
John Arcilla as
President Eleazar "Elias" Sagrado •
Joel Torre as Ernesto "Estong" Malonzo / Emil •
Mylene Dizon as
First Lady Mercedes Ramos-Sagrado •
Rosanna Roces as Nadia Salvacion •
Aiko Melendez as Atty. Divine Torres •
Shaina Magdayao as Grace Malonzo / Cristine ;Supporting cast •
Nikki Valdez as Kendi Velasco •
Joko Diaz as Diego Salvacion •
Jeremiah Lisbo as John Kelvin Velasco •
Daniela Stranner as Maxene Turiano • Alyanna Angeles as Felicia Torres •
Miggs Cuaderno as Macario "Macky" Turiano •
Emilio Daez as Leon Arevalo Jr. • Micaela Santos as
First Daughter Danica Sagrado • Austin Cabatana as Jethro Morales •
River Joseph as Stevenson "Steven" Hermoso • Valentino Jaafar as Tyrone Galarido • Dustine Mayores as Caloy Galang • Sean Tristan as EJ Zamora • Isaiah dela Cruz as Rick Amante • Renshi de Guzman as Aidan Moreno • Luis Vera Perez as Gio Angeles • Beaver Magtalas as Ethan Lim • Angie Castrence as Lolit • Apey Obera as Jelai Liwanag • Ron Angeles as Maj. Vincent Velasquez • Marvin Yap as Randy • Micah Muñoz as Jess Velasco •
Iana Bernardez as Melanie Salvacion •
Claire Ruiz as Shaira Agustin • Mark Manicad as Prof. Benedict Vargas • Dalia Varde as Samantha "Sam" Macalintal • Kei Kurosawa as Cristel Phillips • John Joven Uy as Prof. Elmer • Rocky Labayen as PCPL. Edgar Palermo • JC Galano as PCPL. David Cortez • Carlitos Siguion-Reyna as Gen. Leon Arevalo Sr. • Myrza Sison as Malou Zamora •
Polo Ravales as Eric Marquez • Race Matias as Agent Anthony Torralba •
Cris Villanueva as Henry Torres • Rafa Siguion-Reyna as Atty. Corrales • Jess Mendoza as Gilbert Ysrael • Cheska Iñigo as Luzviminda "Minda" Bautista-Malonzo • Zeppi Borromeo as Arman •
Ryan Eigenmann as Mayor Lorenzo Joaquin •
Ketchup Eusebio as Mattias Turiano • Argel Saycon as Homer • Marella Torre as Lisa • Ross Pesigan as Oska • Junjun Quintana as Lucas • Maxine Trinidad as Queenie Paterno • Angela Okol as Ronaliza "Rona" Cambahiran •
Bodjie Pascua as Sen. Juancho Veracruz • Richard Quan as Dir. Gen. Ulysses Quijada • Lui Villaruz as Agent Manny Callaga • Marc Solis as Agent Jairo Castillo • Patricia Ann Maglaya as Crowd Girl • Kyla Marie Fernandez as Crowd Girl ;Guest cast •
Bela Padilla as Cristine Malonzo / Cristine Pelaez • JC Alcantara as Rolando "Roland" Salvacion •
Harvey Bautista as Percy de Leon • Floyd Tena as Dr. Harvey Hermoso • Nor Domingo as Dr. Yulo •
Jenny Miller as Janette Solis • Al Gatmaitan as Atty. Manuel de Leon • Jonic Magno as Lieutenant Rana ;Notes •
Kyle Echarri is reunited with Alyanna Angeles after the conclusion of
Huwag Kang Mangamba in 2021 with
Daniela Stranner since
Senior High. ==Series overview==