•
Samuel Smith (Connecticut politician) (1646–1735), early settler of Norwalk, Connecticut and deputy of the General Assembly of the Colony of Connecticut in 1691 •
Samuel Smith (1754–1834), British member of parliament (MP) for Leicester, Malmesbury, Midhurst, St Germans and Wendover •
Samuel Smith (Liberal politician) (1836–1906), British MP for Liverpool, 1882–1885 and Flintshire, 1886–1906 •
Samuel Smith Jr., American politician; Democratic member of the Indiana Senate, 1998–2008 •
Samuel Hardman Smith (1868–1956), Canadian politician; municipal politician in Edmonton •
Sam Smith (American politician), state legislator in Washington state and Seattle city councilman •
Sam Smith (Australian politician) (1857–1916), member of the New South Wales Legislative Assembly, Australia •
Samuel Smith (New York politician), mayor of the City of Brooklyn, New York, US, 1850 •
Samuel Smith (Maryland politician) (1752–1839), U.S. senator and representative from Maryland •
Samuel Smith (New Hampshire politician) (1765–1842), U.S. representative from New Hampshire •
Samuel Smith (Pennsylvania politician), U.S. representative from Pennsylvania, 1805–1811 •
Samuel Smith (Upper Canada politician) (1756–1826), American-born Canadian politician; Administrator of Upper Canada, 1817–1818 •
Samuel A. Smith (1795–1861), U.S. representative from Pennsylvania •
Samuel Axley Smith (1822–1863), U.S. representative from Tennessee •
Samuel E. Smith (1788–1860), American politician; governor of Maine, 1831–1834 •
Samuel George Smith (1822–1900), MP for Aylesbury, 1859–1880 •
Samuel H. Smith (politician) (born 1955), American politician; speaker of Pennsylvania House of Representatives •
Samuel James Smith (1897–1964), Australian politician, New South Wales MLC •
Samuel W. Smith (1852–1931), American politician; congressman from Michigan ==In education and academia==