Desjardins first role was in 2011 in
Magic Beyond Words, a
made-for-TV movie about the life of
J.K. Rowling where Desjardins portrays a younger version of Rowling's sister Dianne. That same year, she began a recurring role on the
Netflix series
Project MC2. In the series she portrays Maddy McAlister, the older sister to main character McKeyla, who, along with her friends, is recruited to join a spy organization and use
STEM to save the day. Her character is a top spy agent and must figure out whether her sister has crossed over into the dark side. She describes her character as having two sides, both loving and supportive as well as cold and sinister. The series is set in the same universe as the 2008 science-fiction film
Jumper and is based on the 2013
book of the same name by
Steven Gould. Initially auditioning for the lead role of Henrietta "Henry" Coles, Desjardins instead plays her soon-to-be stepsister, Jenna, whom she grows close to after finding out she was sexually assaulted by a classmate. Desjardins describes her character as multifaceted, being both a popular girl and Henry's confidante after her assault. As well, she describes Jenna as someone who doesn't know what she wants or who she is. The first season premiered on June 6, 2018, while the second premiered on October 16, 2019, however the series was cancelled in March 2020. In 2019, Desjardins began a recurring role on the fourth season of
The CW drama series
Riverdale, as Donna Sweett, a classmate whom
Jughead Jones meets at his new school, Stonewall Prep, and later becomes one of the antagonists. In 2021, Desjardins began a recurring role on the
Showtime series
Yellowjackets as the teenage daughter of Shauna, a woman who survived a plane crash and a lot more when she was in high school. In July 2023, it was announced that Desjardins would join the cast of
Tron: Ares alongside
Jared Leto and
Cameron Monaghan. == Filmography ==