At the age of 18, Natochenny replaced
Veronica Taylor as the voice of
Ash Ketchum on the English-language dub of
Pokémon, starting with the show's
ninth season in 2006, as a result of Pokémon USA bringing their English dubbing work in-house over to TAJ Productions and stepping away from
4Kids Entertainment, who have been dubbing the anime since it first premiered in the West in 1998. They would proceed to do the same thing with all of the other voice actors and their characters. She likened getting the role to "being struck by Pikachu's Thunderbolt" and called it "the most exciting moment of [her] life". She faced some fan backlash for replacing Taylor as Ash, which affected her struggles with
depression: "One [bout of depression] that wasn't circumstantial but was kicked off by the reaction I got when I first started. You're doing what you love, and you finally book your first huge role on a show that you loved as a child and people are like, 'You're terrible.' That's really painful to experience." This would last until 2023, when Ash Ketchum officially left the series at the end of
Pokémon Ultimate Journeys: The Series after more than a quarter-century long run. Despite this, Natochenny still voices various characters and Pokémon in
Pokémon Horizons: The Series, taking a step back into voicing some smaller roles in the show after more than 17 years of voicing Ash Ketchum in the anime, lasting 9 seasons longer than Veronica Taylor did in the anime under 4Kids, who finished her run after 8 years. Natochenny voiced Alicia in the 2006 video game
Bullet Witch. In 2009, she appeared in videos on the comedy website
CollegeHumor. In 2019, she won the Outstanding Animation or Gaming - Demo, Best Voiceover award from the Society of Voice Arts and Sciences. In 2020, she co-starred in the live action pilot
I Adore Dolores, which was one of No Budge's top picks of the year. She also appeared in three videos for
Vanity Fair, talking about the dubbing process and improvising as never-before-seen characters. Natochenny has appeared on multiple episodes of
The George Lucas Talk Show. She is also a film editor, having worked as the primary editor on documentaries for networks such as
MS NOW and an assistant editor on the films
Life of Crime,
Cold Comes the Night,
Worst Friends, and
Cruise. ==Personal life==