Charlotte Makgomo Mannya was born in Ga-Ramokgopa,
Limpopo, South Africa, on 7 April 1871 and grew up in
Fort Beaufort,
Eastern Cape. She was the daughter of John Kgope Mannya, the son of headman Modidima Mannya of the Batlokwa people, under Chief Mamafa Ramokgopa and Anna Manci, a
Xhosa woman from Fort Beaufort. Mannya's father was a roads foreman and Presbyterian lay preacher, and her mother was a teacher. Mannya's grandfather served as a key adviser to the king of the Basothos. Mannya's date of birth is disputed, with possible dates ranging from 1871, 1872 to 1874. The former minister of Home Affairs of South Africa,
Naledi Pandor, took special interest in this detail of Charlotte Maxeke's life, however, no records were found. The 1871 date is also often accepted as it does not conflict with the age of her younger sister Katie, who was born in 1873. At the age of eight, Charlotte Mannya began her primary school classes at a missionary school taught by the Reverend in
Uitenhage. She excelled in
Dutch and
English, mathematics and music. She spent long hours tutoring her less skilled classmates, often with great success. Reverend Wauchope credited her with much of his teaching success particularly with regard to languages. Her musical prowess was visible at a young age. Describing Charlotte's singing Rev. Henry Reed Ngcayiya, a minister of the United Church and family friend said: "She had the voice of an angel in heaven." From Uitenhage, Charlotte moved to
Port Elizabeth to study at the Edward Memorial School under Headmaster
Paul Xiniwe. She excelled and completed her secondary school education in record time, achieving the highest possible grades. In 1885, after the discovery of diamonds, Charlotte moved to
Kimberley, Northern Cape, with her family. ==Foreign travel==