The southern terminus of Highway 19 begins at
Highway 18 between the communities of
Mankota and
Ferland. The highway heads north from there towards
Highway 13 and
Kincaid. After a short eastward
concurrency with 13, Highway 19 resumes its northerly travel en route to
Highway 1 — the
Trans-Canada Highway. Communities along this stretch include
Glenbain and
Hodgeville. Flowing Well Manor, an historic site of Canada, is along the highway about north of Hodgeville. Highway concurrencies along this section include a long one with
43 and a long one with
363. From Highway 1, the two highways begin a eastward concurrency towards
Chaplin and
Chaplin Lake. Chaplin Lake, at an area of , is the second largest
saline lake in Canada. The Western Hemisphere Shorebird Interpretive Centre or the Chaplin Nature Centre is located on Chaplin Lake. In 1947, the Saskatchewan Minerals, the Sodium Sulfate plant opened at Chaplin to mine the abundant salt at the lake. At Chaplin, Highway 19 resumes its northerly routing and heads towards
Thunder Creek where it begins a north-easterly heading for several kilometres. It then returns to its northerly routing and heads to
Central Butte and
Highway 42. Highway 19 has a eastward concurrency with 42 before turning north towards
Lake Diefenbaker. Lake Diefenbaker is a man-made lake along the
South Saskatchewan River impounded by two dams —
Gardiner Dam and
Qu'Appelle River Dam. Highway 19, as it approaches the lake, drops into the Qu'Appelle Valley and runs near the base of the Qu'Appelle River Dam where it crosses the
Qu'Appelle River. After crossing the river, the highway climbs out of the valley and enters
Douglas Provincial Park. It then travels north-west through the park paralleling the eastern shore of Lake Diefenbaker (Gordon McKenzie Arm) and providing access to the park's amenities. As the highway leaves the park, it provides access to
Mistusinne while continuing to parallel the lake en route to
Elbow. After Elbow, the highway resumes its northerly routing and continues northward to its northern terminus at
Highway 15. Communities along the stretch include
Loreburn,
Strongfield, and
Hawarden. == Major intersections ==