The first locomotive (12303) was delivered on 1 February 1920 and the last (12342) on 9 April 1923. Between 1 February and 30 June 1920, the first series (12303-12312) were put into operation from the
Bern depot. They had first proved themselves between
Lötschbergbahn and
Brig-Glis. 12303-12307 were transferred to Erstfeld in early summer 1920 to test for trial the first electrified section of Erstfeld-
Göschenen, returning to Bern between August 1921 and January 1922. In 1924, the entire first series without electric brake (12303-12312) was assigned to the
Zürich depot. With the exception of the 12303, which spent 1929-1947 and 1950–1955 in Bern, they remained based in Zürich until 1962, when they were allotted to the
Winterthur depot until they were phased out. Locomotives 12313-12316 were delivered to Bern from 12 January 1921 to 19 July 1921, and were then transferred to Erstfeld. Locomotives 12317-12342 were delivered directly to the Gotthard between April 1921 and April 1923 and distributed to Erstfeld and
Bellinzona. The depot in Lucerne received 12313–12340 in 1924, some moving to
Olten in November 1927. The Zürich depot was given 12313 and 12314 in 1928 and 1929 and further movements happened as needs changed. Sample distributions are as follows: The Be 4/6 pulled all major express trains on the lines they served, including those between
Schaffhausen and Zürich, until 1929 when the
Ae 4/7 started replacing them. By 1938, the type had been largely replaced by Ae 4/7 and
Ae 8/14 in express service in Gotthard, finally disappearing in 1962 with the increasing introduction of the
Ae 6/6. Freight was also pulled, particularly from the depot at Olten, which served
Basel and Zürich for decades. By 1955, the movement of locomotives to
Biel/Bienne was part of a general trend moving the locomotives to the lowlands. However, they required an ever-increasing amount of repair and maintenance, and retirement started in April 1965 with 12312, with the last locomotive number 12339 discarded in February 1976. ==Preservation==