Green Bay Packers 2018 Valdes-Scantling was selected by the
Green Bay Packers with the 174th overall pick in the fifth round of the
2018 NFL draft. He signed his rookie contract on May 7, 2018. He made his NFL debut in the Packers' season opener against the
Chicago Bears on September 9, 2018, recording a 21-yard kick return in the 24–23 victory. He recorded his first professional reception in the following game against the
Minnesota Vikings. He started his first career game in place of the injured
Randall Cobb in a Week 4 win over the
Buffalo Bills, catching one pass for 38 yards. Still starting in place of Cobb during a Week 5 loss to the
Detroit Lions, Valdes-Scantling had a breakout performance, notching seven receptions for 68 yards and a touchdown. He followed that up with a three-catch, 103-yard performance during a Week 6 win over the
San Francisco 49ers. On October 28, 2018, in a 27–29 loss to the
Los Angeles Rams, he had two receptions for 45 yards, including a 40-yard receiving touchdown. The following week, a 17–31 loss to the
New England Patriots, he had three receptions for 101 yards. Overall, he finished his rookie season with 38 receptions for 581 receiving yards and two receiving touchdowns. He finished seventh among rookies in receiving yards.
2019 In Week 3 against the
Denver Broncos, Valdes-Scantling caught six passes for 99 yards and his first receiving touchdown of the season as the Packers won 27–16. During Week 7 against the
Oakland Raiders, Valdes-Scantling finished with two catches for 133 receiving yards, including a 74-yard touchdown as the Packers won 42–24. Overall, Valdes-Scantling finished the 2019 season with 26 receptions for 452 receiving yards and two receiving touchdowns.
2020 In Week 1 against the Vikings, Valdes-Scantling caught four passes for 96 yards and his first touchdown of the season during the 43–34 win. In Week 9 against the 49ers on
Thursday Night Football, he had two receptions for 53 receiving yards and two touchdowns in the 34–17 victory. In Week 10, against the
Jacksonville Jaguars, he had four receptions for 149 receiving yards, including a 78-yard receiving touchdown, during the 24–20 win. In Week 11 against the
Indianapolis Colts, Valdes-Scantling recorded a key 47-yard catch on a late fourth quarter drive that resulted in a game-tying field goal by
Mason Crosby. However, he also lost a fumble on the Packers' second play in overtime, allowing the Colts to kick the game-winning field goal. Valdes-Scantling later
tweeted that he received death threats after the game. In the
NFC Championship against the
Tampa Bay Buccaneers, Valdes-Scantling recorded four catches for 115 yards and a touchdown during the 31–26 loss.
2021 Valdes-Scantling was placed on
injured reserve on October 2, 2021. He was activated from injured reserve on November 6, 2021. In Week 11, against the Vikings, he had four receptions for 123 yards and a touchdown in the 34–31 loss. He finished the 2021 season with 26 receptions for 430 receiving yards and three receiving touchdowns.
Kansas City Chiefs On March 24, 2022, Valdes-Scantling signed a three-year, $30 million contract with the
Kansas City Chiefs. In Week 7, against the 49ers, he had three receptions for 111 yards in the 44–23 victory. In the 2022 regular season, he had 42 receptions for 687 receiving yards and two receiving touchdowns in 17 games, of which he started 11. In the
AFC Championship Game, Valdes-Scantling caught six passes for 116 yards and a touchdown helping the Chiefs defeat the
Cincinnati Bengals 23–20. Valdes-Scantling won his first Super Bowl championship in the 38–35 victory over the
Philadelphia Eagles in
Super Bowl LVII. He was targeted once with no receptions in the game. Valdes-Scantling caught a career-low 21 passes for 315 yards and just one touchdown in the 2023 regular season. In the
AFC Championship Game against the
Baltimore Ravens, Valdes-Scantling caught a 32-yard pass on third down right before the
two-minute warning, allowing the Chiefs to run out the rest of the clock and beat the Ravens 17–10. In
Super Bowl LVIII, Valdes-Scantling had three receptions for 20 yards and a touchdown in the Chiefs 25–22 victory over the
San Francisco 49ers. On February 28, 2024, he was released.
Buffalo Bills On May 14, 2024, Valdes-Scantling signed a one-year contract with the
Buffalo Bills. On October 15, following the Bills' acquisition of wide receiver
Amari Cooper in a trade with the
Cleveland Browns, Valdes-Scantling was released. While with the Bills, Valdes-Scantling caught two passes for 26 yards on nine targets.
New Orleans Saints On October 22, 2024, Valdes-Scantling signed with the
New Orleans Saints. In Week 10 against the Falcons, he had three receptions for 109 yards and two touchdowns. In his time with the Bills and the Saints, he totaled 19 receptions for 411 yards and four touchdowns.
Seattle Seahawks On March 12, 2025, Valdes-Scantling signed a one-year, $5.5 million contract with the
Seattle Seahawks. He was released on August 26 as part of final roster cuts.
San Francisco 49ers On August 27, 2025, Valdes-Scantling signed with the
San Francisco 49ers' practice squad. He was promoted to the active roster on September 3. On October 17, Valdes-Scantling was placed on injured reserve due to a calf injury, and released the next day.
Pittsburgh Steelers On November 4, 2025, Valdes-Scantling signed with the
Pittsburgh Steelers' practice squad. This reunited him with
Aaron Rodgers, his former quarterback during his tenure in Green Bay. He was promoted to the active roster on December 15. On that same day, he scored a 19-yard receiving touchdown in the 28-15 win over the
Miami Dolphins. He finished the 2025 season with 14 receptions for 120 yards and one touchdown.
Dallas Cowboys On April 27, 2026, Valdes-Scantling was signed to a one-year contract by the
Dallas Cowboys. ==NFL career statistics==