She was born Sehadete Doko on 16 October 1928 in
Koroshishta, Struga,
Kingdom of Yugoslavia (now in
North Macedonia). She pursued secondary studies in 1947 in her native city and then studied medicine in the
Ss. Cyril and Methodius University of Skopje, graduating on 7 January 1954. On 1 April 1954, she started to work in the Hospital of Pristina as a gynecologist and obstetrician. Mekuli specialized in gynecology in March 1960 in
Belgrade. From 1960 until 1962 she was the Chief of the Gynecology and Obstetrics Pavilion of the Pristina Hospital. In 1963, for political reasons, she left the hospital and became Chief of the Dispensary (a
public dispensary), within the House of Health of Pristina. In January 1968, she returned to her position as Chief of the Gynecology and Obstetrics Pavilion in the Pristina Hospital. She also developed a lecture series for schools and dormitories to improve the health education of girls. and siding with the students in their demands as well. Because of her actions, the University of Pristina refused to promote her to full professor, and she was forced into early retirement in October 1988. ==Personal life==