Semiramide Appiani was born in
Florence in 1464. She was the daughter of
Jacopo III Appiano,
Lord of Piombino and relative of the
Aragonas of Naples (his mother was Colia de' Giudici, natural daughter of
Alfonso V of Aragon), and of Battistina Fregoso, daughter of
Genoa doge Battista Fregoso, sister of doge
Pietro Fregoso and maternal half-sister of the famous
Simonetta Vespucci, known for her beauty and alleged lover of
Giuliano de' Medici. In 1478
Lorenzo de' Medici, Giuliano's older brother and Lord of Florence, arranged a betrothal between Giuliano and Semiramide, but the marriage was never held due to Giuliano's death on 26 April 1478 during the
Pazzi conspiracy. As a result, in 1482, Semiramide was given instead in marriage to
Lorenzo di Pierfrancesco de' Medici, a cousin of Lorenzo and his protégé. Five children were born from the marriage. Semiramide died in Florence on 9 March 1523 at fifty-eight age. == Issue ==