Tussilago farfara contains
tumorigenic pyrrolizidine alkaloids.
Senecionine and
senkirkine, present in coltsfoot, have the highest
mutagenetic activity of any pyrrolozidine alkaloid, tested using
Drosophila melanogaster to produce a comparative
genotoxicity test. Two cases of supposed liver damage (and death) due to coltsfoot tea have been shown to actually be the result of mistaken identity. In one, coltsfoot tea causing severe liver problems in an infant was actually the result of
Adenostyles alliariae (alpendost). In another case, an infant developed liver disease and died because the mother drank tea originally believed to contain coltsfoot during her pregnancy, but which was later shown to be
Petasites hybridus (butterbur) or a similar species. In one 27-year-old male, ingesting a multicomponent herbal supplement that included coltsfoot may have caused him to develop non-lethal
deep vein thrombosis and
pulmonary embolism. In response, the German government banned the sale of coltsfoot.
Clonal plants of coltsfoot free of pyrrolizidine alkaloids were then developed in
Austria and
Germany. This has resulted in the development of the registered variety
Tussilago farfara 'Wien', which has no detectable levels of these alkaloids. ==See also==