;June 2, 1937: The Chilean Air Force S-43 (
No. 2) capsized off Ancud, Chile, killing all nine on board. ;August 2, 1937: A
Pan American-Grace Airways (Panagra) S-43B (NC15065) crashed in the vicinity of Coco Solo in the
Panama Canal Zone; all 14 on board died. The plane spiraled into the water at approximately 90 mph and was destroyed by an immediate explosion and fire. The most likely cause of the crash was a faulty gasoline system and/or sudden and severe rain. The pilot indicated he lost altitude twice in the three minutes before the crash. ;August 8, 1937: A
China National Aviation Corporation (CNAC) S-43W (named
Chekiang) ditched at Chilang Point, Bias Bay, China, killing three of four crew; all seven passengers survived. The flying boat was forced to ditch due to bad weather. High waves broke one wing off; the eight survivors clung to the other wing until rescued. ;April 25, 1938:
Pan Am Flight 105, an S-43B (NC16932) stalled and crashed on landing off Kingston due to engine failure; all 18 passengers and crew survived, but the aircraft was written off. ;August 13, 1939:
A Pan Am S-43 (NC16933) crashed into Guanabara Bay off
Rio de Janeiro due to loss of control following engine failure, killing 14 of 16 on board. ;May 17, 1943: Hughes crashed his S-43 into
Lake Mead, killing
CAA inspector Ceco Cline and Hughes employee Richard Felt. The aircraft was later raised and restored to flying condition. ;August 3, 1945: Pan Am Flight 216, an S-43 (NC15066), crashed on landing at Fort de France Hydrobase due to weather and pilot error, killing four of 14 on board. ;January 3, 1947: A
Panair do Brasil S-43B (PP-PBN) crashed in the
Amazon River at São Paulo de Olivenca, killing 11 of 14 on board. ==Surviving aircraft==