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Brión mac Echach Muigmedóin (extant around 362), son of Eochaid Mugmedon •
Brion James, American character actor, starring in
Another 48 Hours •
Brion Vibber, lead developer of Mediawiki software •
Françoise Brion (1933–2025), French film actress •
Friederike Brion, Alsatian muse of Johann Wolfgang von Goethe •
Gustave Brion (1824–1877), French painter and illustrator •
Jon Brion (born 1963), American musician •
Keith Brion (born 1933), American conductor •
Louis Brion de la Tour (1743–1803), French geographer •
Luis Brión (1782–1821), Venezuelan admiral •
Simon de Brion (died 1285), Pope •
Skip Brion, Pennsylvania politician == Fictional characters ==