On his return to Edinburgh, he was appointed surgeon to the
Royal Hospital for Sick Children and the
Royal Infirmary. In 1924 he was appointed to the Regius Chair of Clinical Surgery in succession to Sir Harold Stiles. He was elected a member of the
Harveian Society of Edinburgh. He was elected a fellow of the
Royal Society of Edinburgh in 1928, his proposers being
Arthur Logan Turner,
Harold Stiles, Arthur Robinson,
James Hartley Ashworth and
Sir James Alfred Ewing. In 1935, he left London for Southampton and on to New York on board the RMS 'Aquitania' setting out on a world tour. He travelled overland to Los Angeles and crossed the Pacific to Honolulu, to Samoa, Fiji, New Zealand and Australia. During the journey he visited hospitals and delivered lectures. His journal of the trip is held by Edinburgh University's Heritage Collections. In 1938 he was elected a member of the
Aesculapian Club. He chaired the Advisory Committee on Blood Transfusion which set up blood banks in Scotland in 1939. Fraser's surgical career encompassed paediatric, abdominal, cardiothoracic and breast surgery and he wrote extensively on all of these. two weeks after Oswald Tubbs had successfully ligated an infected ductus in London.
Robert Gross had performed the first in Boston in 1938. Before retiring from surgery Fraser operated on 12 such cases. He was regarded as a major contributor of the golden age for Edinburgh surgery. ==Death and legacy==