Smyrna had been conquered at the beginning of the 14th century by the
Aydinids who had used it since 1326-1329 as base for piracy in the southeastern Mediterranean sea. By the early 1340s the Aydinids and other Turkish beyliks had forced several Aegean islands to pay tributes and had devastated the surrounding coastal regions. The first Smyrniote crusade was the brainchild of
Clement VI. The threat of Turkish piracy in the
Aegean Sea had induced Clement's predecessors,
John XXII and
Benedict XII, to maintain a fleet of four
galleys there to defend Christian shipping, but starting in the 1340s, Clement endeavoured with
Venetian aid to expand this effort into a full military expedition. He commissioned
Henry of Asti, the Catholic
patriarch of Constantinople, to organise a league against the Turks, who had increased their piracy in the Aegean in recent years.
Hugh IV of Cyprus and the
Knights Hospitaller joined, and on 2 November 1342, the Pope sent letters to engage the men and ships of Venice. The
Papal bull granting the
Crusade indulgence and authorising its preaching throughout Europe,
Insurgentibus contra fidem, was published on 30 September. ==First expedition==