Manzano joined the production of
Sesame Street in 1971, where she eventually began writing scripts for the series. On June 29, 2015, it was announced that Manzano would be retiring from the show after 44 years. Manzano did, however, later reprise the role of Maria in the 2019 television special ''
Sesame Street's 50th Anniversary Celebration''. She has performed on the New York stage, in
The Vagina Monologues and
The Exonerated. She has written for the
Peabody Award-winning children's series
Little Bill, and has written a parenting column for the Sesame Workshop web site called "Talking Outloud". She has also appeared in multiple films, including
Death Wish,
Firepower,
Night Flowers,
Wonder Woman in Cheetah on the Prowl,
Sesame Street Presents: Follow That Bird,
The Adventures of Elmo in Grouchland,
The Guitar,
Dumped!,
Missing Grandma, and
Godmothered, and television programs, including
B. J. and the Bear,
Law & Order, and
Law & Order: Special Victims Unit. Manzano is the author of a novel, children's books, and a memoir. In 2015, her memoir,
Becoming Maria: Love and Chaos in the South Bronx, was published. In 2022, her novel for children
Coming Up Cuban was published, as part of a contract with Scholastic to publish two novels and two picture books for children. She has served on the
March of Dimes Board; the
board of the
George Foster Peabody Awards; and the board of a New York City theatrical institution,
Symphony Space. She is a member of the board of advisors of the Project Sunshine Book Club. She was featured in the Learning Leaders (volunteers helping students succeed) poster, designed to encourage reading in NYC public schools. In several episodes of the animated
Nickelodeon series
The Loud House, Manzano provides the voice of Bobby and Ronnie Anne Santiago's grandmother, Rosa Casagrande, a role she reprises in the spin-off
The Casagrandes. She also portrays Judge Gloria Pepitone in
Law & Order: Special Victims Unit. She also provided the voice-over narration in several animated segments in the English version of the Swedish television show
Fem myror är fler än fyra elefanter. On December 3, 2020,
Deadline reported that Manzano would return to
PBS to create a new animated children's television series titled ''
Alma's Way. In Alma's Way'', which was launched by PBS in October 2021, she is the creator, as well as an executive producer, writer, and voice actor. == Honors and awards ==