South Branch Tunkhannock Creek is a tributary of Tunkhannock Creek in Lackawanna County and Wyoming County, in Pennsylvania, in the United States. It is approximately 22.5 miles (36.2 km) long and flows through Scott Township, Benton Township, North Abington Township, and La Plume Township in Lackawanna County and Clinton Township, Factoryville, and Tunkhannock Township in Wyoming County. The watershed of the creek has an area of 98.3 square miles (255 km2). The creek's named tributaries include Trout Brook, Ackerly Creek, and Kennedy Creek. South Branch Tunkhannock Creek is not designated as an impaired waterbody and has relatively good water quality.