The first SC 151 was established in 1927 as a new primary routing between
U.S. Route 29 (US 29)/
SC 15 in
Anderson, to
SC 20 in
Williamston. By 1930, it was renumbered as
SC 248. The current SC 151 was established in 1937 as a renumbering of
SC 35 from Darlington to the
North Carolina state line. By 1952, SC 151 was truncated at
SC 9 in Pageland, its route north to the state line replaced by
US 601. By 1958, SC 151 replaced
SC 151 Alternate (SC 151 Alt.), bypassing
Hartsville. In 1983, SC 151 was extended and bypassed east of
Pageland, to its current northern terminus. In 1997, SC 151 was bypassed east of
Jefferson.
South Carolina Highway 35 South Carolina Highway 35 (
SC 35) was an original
state highway that was established at least as early as 1922 from
SC 41 (now
US 52 Bus.) in
Darlington, through
Hartsville, to
SC 50 (now
US 1) in
McBee. In 1923, it was extended through
Jefferson to
SC 9 in
Pageland. By the end of 1926, it was extended again to the
North Carolina state line, at a point north-northwest of Pageland. In 1938, it was
decommissioned and redesignated as SC 151. ==Major intersections==