Established as an original primary route in 1922, SC 28 went northwest from
Allendale, through
Ellenton, to Beech Island. In 1928, it was extended southeast, replacing
SC 1 from Allendale to
Yemassee, then replaced
SC 30 to
Beaufort. Seven years later, SC 28 was truncated in Yemassee, replaced by an extension of
US 21 to Beaufort. In 1938, SC 28 was extended northwest, going through Georgia as
Georgia State Route 28 to Abbeville (replacing
SC 20); then from Abbeville to Anderson (replacing
SC 18); and finally from Anderson to the Georgia state line along the Chattooga River (replacing
SC 24). In 1940, SC 28 was extended southeast to
Gardens Corner as new primary routing; however, eight years later the extension was dropped, truncated back in Yemassee. In 1951 or 1952, SC 28 between Beech Island and Allendale was cut off by the establishment of the
Savannah River Site. In 1953, SC 28 was rerouted north around the Savannah River Site (replacing part of
SC 781), then along new primary routing south to
Barnwell, and then back to Allendale (replacing part of
SC 3). Most of the old route became part of
SC 125 and
SC 641; other sections, that now reside in the Savannah River Site, are off limits. In 1957 or 1958, two bypass routes were built along SC 28: Seneca and Abbeville; old routes through both cities became SC 28 Business. In 1959, SC 28 was straightened out east of Seneca, avoiding
Newry. In the early 1960s, two more bypass routes were built along SC 28: Anderson and
Pendleton; also, SC 28 was rerouted north and east around Clemson, leaving
SC 93. In 1965, SC 28 was truncated at Beech Island, all points east was replaced by US 278 and
SC 68. In 1973, SC 28 was moved south onto new road between Walhalla and
Bounty Land, the old route became "Old Walhalla Highway". ==Junction list==