The series follows
Peter Parker, a college student at Empire State University who struggles to balance his responsibilities as the costumed hero Spider-Man with the problems of his personal life. In addition to fighting crime, Peter must navigate his romantic affections for love interests
Felicia Hardy and
Mary Jane Watson; maintain his friendship with
Harry Osborn; focus on his academic performance as
Dr. Curt Connors' student; and help to support his
Aunt May after the death of his
Uncle Ben by working as a freelance photographer for the
Daily Bugle. The Bugle is owned by loudmouth publisher
J. Jonah Jameson, who often uses Peter's pictures of his alter-ego to discredit and carry out a
smear campaign against Spider-Man. Peter's peers at ESU include football star
Flash Thompson, popular barista
Liz Allan, scientific genius
Debra Whitman, and research rival
Michael Morbius. As Spider-Man, Peter faces various supervillains who threaten New York City, including criminal masterminds such as the
Kingpin and the
Hobgoblin, scientific mishaps like
Doctor Octopus and the
Green Goblin, and the extraterrestrial
symbiotes Venom and
Carnage. Spider-Man is occasionally aided in his fight against crime by other superheroes, including the
X-Men, the
Punisher,
Blade,
Doctor Strange,
Daredevil,
Iron Man,
Captain America, and the
Fantastic Four.
Adaptations A large number of storylines and events from the comics are loosely adapted in the series, such as:
Season 1 • The first episode, "Night of the Lizard", is loosely based on the comic story "Face-to-Face with... the Lizard!" from
The Amazing Spider-Man #6 (November 1963). • The episode "The Spider Slayer" is loosely based on the comic story "Captured by J. Jonah Jameson!" from
The Amazing Spider-Man #25 (June 1965), with the subplot of Flash Thompson dressing up as Spider-Man to scare Peter Parker being taken from "Marked for Destruction by Dr. Doom!" from
The Amazing Spider-Man #5 (October 1963). • The episode "Return of the Spider Slayer" borrows elements from the comic books including the way Alistair Smythe treated Spider-Man and Jameson in a very similar way to how his father Spencer Smythe treated them in the comic story "24 Hours till Doomsday!" in
The Amazing Spider-Man #192 (May 1979), the three spider slayers are from "Invasion of the Spider Slayers Part 5: Arachnophobia Too!" from
The Amazing Spider-Man #372 (January 1993) and Mary Jane uses her famous line from her first comic appearance: "Face it, Tiger. You just hit the jackpot", in the comic story "The Birth of a Super-Hero!" from
The Amazing Spider-Man #42 (November 1966). • The episode "Doctor Octopus: Armed and Dangerous" is loosely based on the comic story "Spider-Man Versus Doctor Octopus" from
The Amazing Spider-Man #3 (July 1963). • The episode "The Menace of Mysterio" is loosely based on the comic story "The Menace of... Mysterio!" from
The Amazing Spider-Man #13 (June 1964). • The episode "The Sting of the Scorpion" is based on the comic story "Spidey Strikes Back!" / "The Coming of the Scorpion! OR: Spidey Battles Scorpey!" in
The Amazing Spider-Man #19-20 (December 1964–January 1965). • The episode "Kraven the Hunter" is loosely adapted from the comic story of the same name from
The Amazing Spider-Man #15 (August 1964). • The dream sequence from the episode "The Alien Costume, Part One" where the symbiote and the Spider-Man costume fight over Peter Parker is adapted from the comic story "The Sinister Secret of Spider-Man's New Costume!" from
The Amazing Spider-Man #258 (November 1984). • The end of the episode "The Alien Costume, Part Two" where Spider-Man uses the bell to get free from the symbiote is adapted from the comic story "'Til Death Do Us Part!" from
Web of Spider-Man #1 (April 1985). • The beginning of the episode "The Alien Costume, Part Three" where Eddie Brock has a wall covered with newspaper clippings of Spider-Man and turns into Venom swearing vengeance on Spider-Man is adapted from the comic story "Chance Encounter" from
The Amazing Spider-Man #298 (March 1988), while the scene where Eddie menaces Peter at Aunt May's home is adapted from the story "The Sand and the Fury" from
The Amazing Spider-Man #317 (July 1989). • "The Hobgoblin" two-parter is loosely adapted from the comic stories "Secrets!" / "Confessions!" / "Endings!" from
The Amazing Spider-Man #249-251 (February–April 1984). • The episode "Day of the Chameleon" is loosely adapted from the comic story "Spider-Man Vs. the Chameleon!" from
The Amazing Spider-Man #1 (March 1963).
Season 2 • The episode "The Insidious Six" "and "Battle of the Insidious Six" are both based on the comic story "The Sinister Six!" from
The Amazing Spider-Man Annual #1 (October 1964). • In "Battle of the Insidious Six" the scene where Peter is unmasked by the Insidious Six, after Aunt May is kidnapped by them (but he manages to convince them that he is a fraud) is from the comic story "Unmasked By Doctor Octopus!" from
Amazing Spider-Man #12 (May 1964) but instead of Aunt May, it's Betty Brant who is kidnapped by Doctor Octopus by himself. • The episode "Hydro-Man" is based on the comic story "The Coming of Hydroman!" from
The Amazing Spider-Man #212 (January 1981). • The episodes "The Mutant Agenda" and "Mutants' Revenge" are based on
Spider-Man: The Mutant Agenda #1-3 (March–May 1994). • The episodes "Morbius" and "Enter the Punisher" are both based on the comic stories "The Spider or the Man?" / "A Monster Called Morbius!" / "Vampire at Large!" from
The Amazing Spider-Man #100-102 (September–November 1971). The Man-Spider plot is loosely adapted from "Fast Descent into Hell!" / "To Sacrifice My Soul..." from
Marvel Fanfare #1-2 (March–May 1982). • "Enter the Punisher" is also based on the comic story "The Punisher Strikes Twice!" from
The Amazing Spider-Man #129 (February 1974). • The episode "Tablet of Time" is based on the comic story "The Web Closes!" from
The Amazing Spider-Man #73 (June 1969) with Smythe's robot originating from "Invasion of the Spider Slayers Part 4: One Clue Over The Cuckoo's Nest" from
The Amazing Spider-Man #371 (December 1992). • The episode "Ravages of Time" is based on the comic stories "If This Be Bedlam!" / "Death Without Warning!" from
The Amazing Spider-Man #74-75 (July–August 1969) and "Lifetheft Part One: The Wings of Age" / "Lifetheft Part Two: The Thief of Years" / "Lifetheft Part Three: The Sadness of Truth" from
The Amazing Spider-Man #386-388 (February–April 1994). • The episode "Shriek of the Vulture" is based on the comic stories "Duel to the Death with the Vulture!" from
The Amazing Spider-Man #2 (May 1963) and "The Wings of Age!" from
The Amazing Spider-Man #386 (February 1994). • The episode "The Final Nightmare" is loosely based on "The Thief of Years" from
The Amazing Spider-Man #387 (March 1994).
Season 3 • The episode "Make a Wish" is based on the comic stories "Doc Ock Wins!" from
The Amazing Spider-Man #55 (December 1967) and "
The Kid Who Collects Spider-Man!" from
The Amazing Spider-Man #248 (January 1984). A flashback to Spider-Man's origin is shown and is adapted from the comic story "Spider-Man!" from
Amazing Fantasy #15. • The episode "Attack of the Octobot" is based on the comic stories "Disaster!" from
The Amazing Spider-Man #56 (January 1968) and "The Kid Who Collects Spider-Man!" from
The Amazing Spider-Man #248 (January 1984). • The episode "Rocket Racer" is based on the comic stories "The Fiend from the Fire!" from
Amazing Spider-Man #172 (September 1977) and "The Rocket Racer's Back in Town!" / "...And Where the Big Wheel Stops, Nobody Knows!" from
The Amazing Spider-Man #182-183 (July–August 1978). • The episode "The Ultimate Slayer" is loosely based on the comic story "Invasion of the Spider Slayers Part 6: The Bedlam Perspective" from
The Amazing Spider-Man #373 (January 1993). • The episode "Tombstone" is loosely based on the comic stories "Grave Memory" from
The Spectacular Spider-Man #139 (June 1988) and "Will!" from
The Spectacular Spider-Man #142 (September 1988). • The episode "Venom Returns" is blended from several different comics including "Hearts and Powers" / "Gun From the Heart" from
The Amazing Spider-Man #344-345 (February–March 1991) and "Toy Death!" from
The Amazing Spider-Man #359 (February 1992). • The episode "Carnage" is loosely based on the comic stories "Savage Genesis" / "Savage Alliance" / "Savage Grace!" from
The Amazing Spider-Man #361-363 (April–June 1992). • The episode "The Spot" is based on the comic story "True Confessions!" / "Spider on the Spot!" from
Peter Parker, the Spectacular Spider-Man #98-99 (January–February 1985). • The episode "Goblin War!" is based on the comic story "The Goblin War" from
The Amazing Spider-Man #312 (February 1989). • The episode "Turning Point" is based on the comic stories "How Green Was My Goblin!" from
The Amazing Spider-Man #39 (August 1966) and
"The Night Gwen Stacy Died" / "The Goblin's Last Stand!" from
The Amazing Spider-Man #121-122 (June–July 1973).
Season 4 • The episode "Guilty" is based on "Guilty!" / "Lock-Up" from
The Spectacular Spider-Man #150-151 (May–June 1989) and "Crash Out!" from
The Spectacular Spider-Man #155 (October 1989). • The episode "The Black Cat" is based on "Never Let the Black Cat Cross Your Path!" from
The Amazing Spider-Man #194 (July 1979). • The episode "The Return of the Green Goblin" is based on "The Green Goblin Lives Again!" / "The Green Goblin Strikes!" from
The Amazing Spider-Man #136-137 (September–October 1974).
Season 5 • The episode "The Wedding" is loosely based on "The Wedding" from
The Amazing Spider-Man Annual #21 (September 1987). • The "Six Forgotten Warriors" saga is loosely based on "The Parents of Peter Parker!" from
The Amazing Spider-Man Annual #5 (November 1968) and "The Assassin-Nation Plot" storyline from
The Amazing Spider-Man #320-325 (September 1989–November 1989). • The "Secret Wars" trilogy adapts the 1984 limited series
Marvel Super Heroes Secret Wars (May 1984–April 1985). • The "Spider Wars" duology adapts the second "
Clone Saga" (October 1994–December 1996).
John Semper would later claim that this arc inspired
Dan Slott's "
Spider-Verse" storyline. ==Episodes==