Van Houten played her first leading role in
Martin Koolhoven's
TV film Suzy Q. She won a
Golden Calf for her part as Suzy. She also won the Pisuisse Award and the Top Naeff Award for her stage acting and another Golden Calf for her part as the kitten that becomes a woman in
Miss Minoes (2001). The first time she could be seen in cinemas in the U.S. was when Martin Koolhoven's
AmnesiA (2001) got a small theatrical release. Van Houten won a Golden Calf for her performance as Rachel Stein in
Black Book (2006) at the
Netherlands Film Festival.
Black Books director
Paul Verhoeven said about her in a television interview: "Never in my life I have worked with an actress this talented", and when asked to compare her with
Sharon Stone he said "Carice can really act." The international press was also enthusiastic about her role in
Black Book. In December 2006, van Houten withdrew from a theatre production of
Alex van Warmerdam for personal reasons. According to a theatre spokesman it was because of a work overload. In 2008, she starred in the non-commercial short movie
Zingen in het donker (English:
Singing in the dark), a drama on domestic violence. She appeared in the magazine
Vanity Fair in the issue for March 2008, photographed by Wayne Maser. In 2008, van Houten had a role opposite
Leonardo DiCaprio in
Body of Lies but her scenes did not make the final cut of the movie. In April 2009, it was announced that van Houten would star in
Black Death by British director
Christopher Smith and in the Dutch film
Komt een vrouw bij de dokter (English title:
Stricken), based on the novel of the same name by
Ray Kluun. She also starred in the science fiction thriller
Repo Men. In July 2011, van Houten was cast as the priestess
Melisandre in the second season of
HBO's fantasy TV series
Game of Thrones. Her performance has garnered her praise and recognition, earning her a
Primetime Emmy Award nomination for
Outstanding Guest Actress in a Drama Series for her final performance as the character in the season 8 episode "
The Long Night" in 2019. After nominations were announced for the ceremony, van Houten received considerable media attention for having been one of the three nominated actors from the show to have self-submitted and paid entry fees to be on the ballot for Emmy consideration after HBO had not done so for them. She has also received three
Screen Actors Guild Award nominations for
Outstanding Performance by an Ensemble in a Drama Series in 2014, 2016, and 2017 for the role. In 2012, van Houten appeared in
Antony and the Johnsons' "Cut the world" video, which was directed by
Nabil Elderkin and also starred
Willem Dafoe and
Marina Abramović. In 2019, van Houten starred as a prison therapist that becomes infatuated with one of her patients, a serial rapist, in
Halina Reijn's directorial debut
Instinct. The film premiered at the
Locarno Film Festival, receiving the Variety Piazza Grande Award and was selected as the Dutch submission for
Best International Feature Film at the
92nd Academy Awards.
Varietys Guy Lodge described van Houten as being "on electrifying form" and Reijn's direction "provides a fearsome reminder" of the former's breakthrough performance in
Black Book. She narrates the Dutch-language version of
Steve McQueen's 2023 film
De Bezette Stad (
Occupied City). ==Personal life==