MD 68 begins at an intersection with US 40 (Cumberland Street) in the town of Clear Spring. The state highway heads south as four-lane undivided Mill Street through a commercial area. MD 68's name changes to Clear Spring Road after leaving the town limits. The state highway meets I-70 (Eisenhower Memorial Highway) at a
diamond interchange, then heads southeast through farmland as a two-lane undivided road, where the highway crosses Little Conococheague Creek. MD 68 intersects the eastern end of
MD 56 (Big Pool Road) shortly before passing through the village of
Pinesburg. The state highway intersects
CSX's
Lurgan Subdivision rail line at-grade and passes between industrial properties, then crosses
Conococheague Creek and enters the town of Williamsport. MD 68 is municipally maintained within the town, where the highway follows Conococheague Street south through an intersection with US 11 (Potomac Street). At this intersection, MD 63 joins MD 68 in a concurrency to continue through the
Williamsport Historic District. The two highways leave the town limits at their diamond interchange with I-81 (Maryland Veterans Memorial Highway), through which the roadway temporarily expands to a four-lane
divided highway. A
park and ride lot is located within the northwest quadrant of this interchange. MD 68's name changes to Lappans Road south of Williamsport. MD 63 (Spielman Road) splits south from MD 68 at the same intersection as Governor Lane Boulevard, which serves an industrial park. MD 68 crosses over a
Winchester and Western Railroad line and curves to the east, then resumes heading southeast after intersecting the eastern end of Kendle Road. The state highway heads southeast through farmland and intersects
MD 632 (Downsville Pike). The road crosses
Norfolk Southern Railway's
Hagerstown District at-grade and crosses St. James Run in the hamlet of
St. James. MD 68 intersects
MD 65 (Sharpsburg Pike) in the hamlet of
Lappans, where the highway passes north of
St. Mark's Episcopal Church. The state highway passes through the hamlet of Brethedsville and passes Devils Backbone County Park as the highway follows
Antietam Creek for a short distance. MD 68 crosses over the creek on a narrow stone bridge, then makes a sharp turn to the south to continue following the forested valley of the creek. The state highway crosses over Beaver Creek on a one-lane stone bridge before leaving the creek valley. MD 68 continues southeast through farmland and the hamlet of Millpoint before reaching its eastern terminus at US 40 Alternate (Main Street) on the northern edge of the town of Boonsboro. ==History==