Pre-draft Coming out of Notre Dame, Tuitt was projected by the majority of analysts to be a first or second-round pick. He was invited to the
NFL Scouting Combine but was able only to perform the
bench press due to a foot injury. Scouts were conflicted as to whether Tuitt was more apt to be a
defensive tackle or a defensive end in the NFL. On March 14, 2014, Tuitt attended Notre Dame's
pro day and performed for 59 team representatives and scouts from all 32 teams.
Jacksonville Jaguars head coach
Gus Bradley and
Pittsburgh Steelers head coach
Mike Tomlin were the only coaches who attended. Tomlin flew to South Bend specifically to meet with Tuitt, although he was unable to perform physically after having surgery on his foot the previous week. He was ranked as the second best defensive end prospect in the draft by NFL analyst
Mike Mayock, was ranked the fourth best defensive tackle prospect by NFLDraftScout.com, and the sixth best defensive tackle by
Sports Illustrated.
2014 The Steelers drafted Tuitt in the second round (46th overall) of the
2014 NFL draft. On June 18, 2014, the Steelers signed him to a four-year, $4.60 million contract with $2.72 million guaranteed and a signing bonus of $1.67 million. He entered
training camp his rookie year, competing with
Cameron Heyward,
Brett Kiesel, and
Cam Thomas for a starting defensive end position. To begin the regular season, he was named the backup weakside defensive end behind Heyward. He made his professional regular season debut in the Steelers' season-opener against the
Cleveland Browns. The next game, he recorded his first career tackle in the Steelers' 26–6 loss to the
Baltimore Ravens. On December 7, 2014, he made his first career start against the
Cincinnati Bengals and finished the 42–21 victory with two combined tackles. In Week 16, Tuitt collected a season-high three solo tackles and made his first career sack on
Kansas City Chiefs quarterback
Alex Smith. He also forced a fumble from Chiefs' running back
Jamaal Charles and helped the Steelers defeat the Chiefs, 20–12. He finished his rookie season with 19 combined tackles, one sack, one forced fumble, and a fumble recovery while appearing in all 16 regular season games and starting four of them. He received an overall grade of 43.0 from
Pro Football Focus (PFF) in 2014. The Steelers finished the season with an 11–5 record to clinch an
AFC North pennant. On January 3, 2015, he appeared in his first career playoff game and made two solo tackles as the Steelers lost, 30–17, in the
AFC Wildcard game to the Ravens.
2015 Tuitt entered training camp competing for the vacant starting defensive end position left by the retirement of
Brett Kiesel. He was named a starting defensive end to begin the season, after beating out teammates Cam Thomas,
Leterrius Walton,
Clifton Geathers,
Caushaud Lyons, and
Joe Kruger. He started the season opener against the
New England Patriots and assisted on one tackle during the 21–28 loss. The next game, Tuitt made four combined tackles and 1.5 sacks on
San Francisco 49ers quarterback
Colin Kaepernick, helping the Steelers win, 43–18. On September 27, 2015, he collected seven combined tackles and a sack on
St. Louis Rams quarterback
Nick Foles. The following week, Tuitt made a career-high ten solo tackles and sacked Ravens' quarterback
Joe Flacco during the Steelers' 20–23 loss. During a Week 14 matchup against the Bengals, Tuitt recorded his first career interception off a shovel pass from quarterback
Andy Dalton. In the last game of the season, a victory over the Browns, he racked up four total tackles and a season-high two sacks on Brown's quarterback
Austin Davis. He was voted AFC Defensive Player of the week for his performance over Cleveland. During a Week 15 matchup against the Bengals]l, Tuitt left the game after suffering a knee injury on the first drive and missed the next two games. Tuitt received an overall grade of 82.0 from Pro Football Focus and was ranked 21st among all qualified interior defensive linemen in 2016. He finished the regular season with 37 combined tackles (29 solo), four sacks, and three pass deflections in 14 games and 14 starts. The Steelers finished first in the
AFC North with an 11–5 record. On January 8, 2017, Tuitt recorded four combined tackles in a 30–12 AFC Wildcard game victory over the
Miami Dolphins.
2017 On September 9, 2017, the Steelers signed Tuitt to a five-year, $60 million contract extension with an $11 million signing bonus and $13 million guaranteed. After returning for two games, Tuitt then suffered a back injury that kept him out of Weeks 7–8. In Week 17, he collected a season-high five combined tackles during a 28–24 win against the Browns. He finished the season with 25 combined tackles (19 solo), three sacks, and two pass deflections in 12 games and 12 starts.
2018 In week 8 against the Browns, Tuitt recorded 7 tackles, 1 sack, and 1 pass defended as the Steelers won 33–18. In week 10 against the
Carolina Panthers, Tuitt hyper extended his elbow and missed the next two games against the Jaguars and Broncos. He made his return in week 13 against the
Los Angeles Chargers. Tuitt finished the season with 45 tackles, 5.5 sacks, and 4 passes defended. He received an overall grade of 81.8 from
Pro Football Focus in 2018, which ranked as the 21st highest grade among all qualifying interior defenders.
2019 In Week 2 against the
Seattle Seahawks, Tuitt sacked
Russell Wilson 2.5 times as the Steelers lost 28–26. In Week 3 against the 49ers, Tuitt recorded a sack on
Jimmy Garoppolo in the 24–20 loss. On October 15, 2019, he was placed on
injured reserve after suffering a torn pec in a Week 6 game against the Chargers.
2020 Tuitt made his return from injury in Week 1 against the
New York Giants on
Monday Night Football. During the game, Tuitt recorded his first sack of the season on
Daniel Jones in the 26–16 win. In Week 5 against the Eagles, Tuitt recorded 1.5 sacks on
Carson Wentz during the 38–29 win. Tuitt's 3.5 sacks during the first four games of the 2020 season tied his previous season's total. In Week 8 against the Ravens, Tuitt recorded nine tackles and two sacks on
Lamar Jackson during the 28–24 win. On November 4, 2020, Tuitt was named the AFC Defensive Player of the Week for his performance in Week 8. In Week 11 against the Jaguars Tuitt recorded his seventh sack (single season career high) of the season on
Jake Luton during the 27–3 win. He was placed on the reserve/
COVID-19 list by the team on November 27, 2020, and activated on December 5. In Week 16 against the
Indianapolis Colts, Tuitt recorded his tenth sack of the season on
Philip Rivers during the 28–24 win. He finished the season with a career high 11 sacks, as well as 45 tackles and 2 forced fumbles.
2021 On September 1, 2021, Tuitt was placed on injured reserve to start the season. While coping with the death of his brother and dealing with a lingering knee injury, he did not play in a single game during the 2021 season
2022 On June 1, 2022, Tuitt announced his retirement from professional football. ==Career statistics==