STK19

STK19 contains 3 different protein-interaction domains, which are essential to its function in DNA repair: the CSA interacting domain, RNA polymerase II (RNAPII) interacting domain, and UVSSA interacting domain. These domains allow STK19 to incorporate into the Transcription-Coupled DNA Repair (TCR) complex, which is recruited to RNA Polymerase II stalled at DNA lesions. Part of the UVSAA binding domain may also interact with XPD, a protein in the TFIIH (transcription factor IIH) complex. This complex is recruited to the TCR and is involved in excising the damaged DNA. STK19 binding to XPD is theorized to help optimally position the TFIIH ATPase subunits XPD and XPB onto the DNA in front of the lesion. == Role in transcription coupled nucleotide excision repair ==

STK19 is involved in transcription-coupled nucleotide excision repair (TC-NER), a DNA repair pathway that preferentially detects and removes DNA damage in portions of the genome that are being actively transcribed (copied from DNA into RNA). By contrast, the non-transcribed strand and portions of the genome not under active transcription are repaired more slowly, using global genome nucleotide excision repair (GG-NER). == See also ==