Tyrrell made her Broadway debut in 1965 as a replacement performer in the comedy
Cactus Flower. In 1968, as a member of the
Repertory Theatre of Lincoln Center, she was in the cast of
King Lear and revivals of
The Time of Your Life (1969) and
Camino Real (1970).
Off-Broadway, Tyrrell appeared in the 1967 premiere of
Lanford Wilson's
The Rimers of Eldritch and a 1979 production of ''
Father's Day (play)'' at
The American Place Theatre. Tyrrell's television debut was in
Mr. Novak (1964) and her film debut was in
Shoot Out (1971). Tyrrell was nominated for an
Academy Award for Best Supporting Actress for her performance as Oma in
John Huston's
Fat City (1972). In 1976, she played a psychotic character in
I Never Promised You A Rose Garden. In 1978, she won the
Saturn Award for Best Supporting Actress for her performance in
Bad. Later, Tyrrell starred as Queen Doris in the
indie Forbidden Zone (1980). She sang the film's song, "Witch's Egg". A year later, she portrayed Vera in
Tales of Ordinary Madness (1981). From 1981 to 1982, Tyrrell starred as Gretchen Feester, in the
ABC's short-lived
situation comedy series
Open All Night. She then had a starring role in the
exploitation horror film Butcher, Baker, Nightmare Maker (1981). In 1983, Tyrrell played Solly in the sexploitation film
Angel and its 1984 sequel,
Avenging Angel. Then followed roles in the adventure film
Flesh+Blood, the
Vincent Price anthology horror film From a Whisper to a Scream (1987), the
animated feature film The Chipmunk Adventure (1987), and
Big Top Pee-wee (the 1988 sequel to 1985's ''
Pee-wee's Big Adventure''). Tyrrell took a supporting role in
John Waters'
Cry-Baby (1990). In 1992, she guest starred on an episode of Wings "Marriage Italian Style" and she performed her own one-woman show,
Susan Tyrrell: My Rotten Life, a Bitter Operetta. In the late 1990s, Tyrrell had roles in the
Tales from the Crypt episode "Comes the Dawn" (1995), the
animated series Extreme Ghostbusters (1997), and the
psychological thriller film
Buddy Boy (1999). In the 2000s, Tyrrell appeared in
Bob Dylan's
Masked and Anonymous (2003) and ''The Devil's Due at Midnight
(2004). Her final appearance was in the 2012 independent film Kid-Thing''. ==Personal life==