Pre-draft NFL.com lead analyst Lance Zierlein projected Hufanga to be selected in the fourth or fifth round of the 2021 NFL Draft.
Bleacher Report had him ranked as the 12th best safety prospect and projected him to be selected in the fourth round. Dane Brugler of
the Athletic had Hufanga ranked as the eighth best safety prospect.
Scouts Inc. had him as the 20th best safety in their big board (212th overall).
San Francisco 49ers 2021 The
San Francisco 49ers selected Hufanga in the fifth round (180th overall) of the
2021 NFL draft. He was the 14th safety drafted in 2021. On May 13, 2021, the 49ers signed Hufanga to a four-year, $3.72 million rookie contract that includes an initial
signing bonus of $240,152. Throughout
training camp, Hufanga competed to be the starting strong safety against
Tavon Wilson,
Tarvarius Moore, and
Jaquiski Tartt. Head coach
Kyle Shanahan named Hufanga the No. 2 strong safety on the depth chart to begin the season. Hufanga made his professional regular season debut during the season-opening 41–33 road victory over the
Detroit Lions, but saw limited snaps on defense and special teams. During Week 8 against the
Chicago Bears, Hufanga earned his first career start in place of Jaquiski Tartt, who was placed on injured reserve. Hufanga finished the 33–22 road victory with a season-high five tackles. Two weeks later against the
Los Angeles Rams on
Monday Night Football, Hufanga recorded three tackles and a pass deflection in the 31–10 victory. During a Week 12 34–26 victory over the
Minnesota Vikings, Hufanga had two tackles and a pass deflection. Two weeks later against the
Cincinnati Bengals, he tied his season-high of five tackles in the 26–23 overtime road victory. Hufanga was inactive for two games (Weeks 16–17) due to a knee injury. Hufanga finished his rookie year with 32 tackles and two pass deflections in 15 games and three starts. He received an overall grade of 62.5 from
Pro Football Focus as a rookie. The 49ers finished third in the
NFC West with a 10–7 record and qualified for the playoffs as the #6-seed. In the
Divisional Round against the
Green Bay Packers, Hufanga made his postseason debut and scored his first NFL touchdown after returning a punt that was blocked by defensive lineman
Jordan Willis during the fourth quarter of the 13–10 road victory.
2022 During training camp, Hufanga competed to be a starting safety against
Tayler Hawkins,
Leon O'Neal Jr., and
George Odum. Head coach Kyle Shanahan named him the starting strong safety to begin the season alongside
Tashaun Gipson. During the season-opening 19–10 road loss to the Bears, Hufanga had a team-high 11 tackles, a pass deflection, and an interception. In the next game against the
Seattle Seahawks, he recorded six tackles and two pass deflections during the 27–7 victory. Two weeks later against the Rams on
Monday Night Football, Hufanga had four tackles, a pass deflection, and a 52-yard pick six in the 24–9 victory. During Week 5 against the
Carolina Panthers, Hufanga recorded five tackles, a pass deflection, and his first NFL sack on
Baker Mayfield in the 37–15 road victory. Two weeks later against the
Kansas City Chiefs, he had four tackles, a pass deflection, and an interception in the 44–23 loss. During a Week 10 22–16 victory over the
Los Angeles Chargers on
Sunday Night Football, Hufanga recorded two tackles, a pass deflection, and an interception. During a Week 12 13–0 shutout victory over the
New Orleans Saints, Hufanga had a team-high nine tackles and a forced fumble. Three weeks later against the Seahawks on
Thursday Night Football, he recorded five tackles, a pass deflection, and a strip-sack as the 49ers clinched the
NFC West with a 21–13 road victory. In the next game against the
Washington Commanders, he had eight tackles and a pass deflection during the 37–20 victory. Hufanga finished his second professional season started with 97 tackles, nine pass deflections, a career-high four interceptions, two forced fumbles, and a sack in 17 games and starts. He earned a
Pro Bowl nomination and first team
All-Pro honors. Hufanga received an overall grade of 72.1 from Pro Football Focus in 2022. The 49ers finished atop the NFC West with a 13–4 record and qualified for the playoffs as the #2-seed. During the Wild Card Round against the Seahawks, Hufanga made his first career start in a playoff game and finished the 41–23 victory with five tackles. In the Divisional Round against the
Dallas Cowboys, Hufanga once again had five tackles during the 19–12 victory. During the NFC Championship Game against the
Philadelphia Eagles, he had six tackles and a pass deflection in the 31–7 road loss. Hufanga was ranked 78th by his fellow players on the
NFL Top 100 Players of 2023.
2023 On February 9, 2023, the 49ers hired
Steve Wilks to be their new defensive coordinator after
DeMeco Ryans accepted the head coaching position with the
Houston Texans. Head coach Kyle Shanahan named Hufanga as the starting strong safety to begin the season and paired him with Tashaun Gipson. During the season-opening 30–7 road victory over the
Pittsburgh Steelers, Hufanga had five tackles, a pass deflection, and an interception. Two weeks later against the
New York Giants on
Thursday Night Football, he recorded a tackle, a pass deflection, and an interception in the 30–12 victory. During Week 8 against the
Cincinnati Bengals, Hufanga recorded a team-high 10 tackles (tied with
Isaiah Oliver and
Fred Warner) in the 31–17 loss. Following a Week 9 bye, the 49ers went on the road to face the
Jacksonville Jaguars. Hufanga finished the 34–3 blowout victory with a team-high eight tackles (tied with
Dre Greenlaw), a pass deflection, and an interception. In the next game against the
Tampa Bay Buccaneers, he recorded a tackle before leaving the eventual 27–14 victory during the third quarter with a knee injury. It was later revealed that Hufanga tore his ACL, prematurely ending his season. Hufanga was placed on
injured reserve on November 21. Hufanga finished the 2023 season with 52 tackles, three interceptions, and three pass deflections in 10 games and starts. Without him, the 49ers reached
Super Bowl LVIII, where they lost in overtime by a score of 25–22 to the Chiefs.
2024 Hufanga remained on injured reserve for the first two games of the season. He made his season debut in Week 3 against the Rams and finished the 27–24 road loss with seven tackles. However, Hufanga missed the next game against the
New England Patriots due to an ankle injury he suffered in practice a few days before the game. The following week against the Cardinals, Hufanga made a tackle before leaving the eventual narrow 24–23 loss in the second quarter with a wrist injury. On October 9, 2024, the 49ers officially placed him on injured reserve due to torn ligaments in his wrist. On December 7, Hufanga was activated off of injured reserve after being inactive for seven consecutive games (Weeks 6–13). He returned from injury the next day against the Bears and recorded five tackles in the 38–14 victory. In the next game against the Rams on
Thursday Night Football, Hufanga recorded a season-high eight combined tackles (two solo) during the 12–6 loss. Hufanga finished the 2024 season with 38 combined tackles (20 solo) in seven games and starts. He received an overall grade of 57.8 from
Pro Football Focus.
Denver Broncos 2025 On March 10, 2025, the
Denver Broncos signed Hufanga to a three-year, $45 million contract with $20 million guaranteed. Hufanga made his Broncos debut in the season-opener against the
Tennessee Titans and finished the 20–12 victory with a team-high 11 tackles and a forced fumble. In the next game against the
Indianapolis Colts, Hufanga had 10 tackles during the narrow 29–28 road loss. The following week against the Chargers, he recorded six tackles and two pass deflections in the 23–20 road loss. During a Week 5 21–17 road victory over the reigning
Super Bowl-champion Eagles, Hufanga had a team-high seven tackles and a pass deflection. In the next game against the
New York Jets in London, he recorded five tackles, a pass deflection, and his first sack of the season on Justin Fields during the narrow 13–11 victory. The following week against the Giants, Hufanga had five tackles and two pass deflections in the narrow 33–32 comeback victory. During Week 9 against the Texans, Hufanga recorded nine combined tackles and two pass deflections in the 18–15 road victory. In the next game against the
Las Vegas Raiders on
Thursday Night Football, he had a team-high nine combined tackles (five solo) and his second sack of the season on
Geno Smith during the 10–7 victory. The following week against the Chiefs, Hufanga recorded six tackles and a pass deflection in the 22–19 victory. Following a Week 12 bye, the Broncos went on the road to face the Commanders. Hufanga finished the narrow 27–26 overtime victory with a season-high 13 tackles and a pass deflection. Three weeks later against the Jaguars, he had four tackles and a pass deflection in the 34–20 loss. Hufanga finished the 2025 season with 106 tackles, 11 pass deflections, two sacks, and a forced fumble in 17 games and starts. The Broncos finished atop the
AFC West with a 14–3 record and qualified for the playoffs as the #1-seed. In the Divisional Round against the
Buffalo Bills, Hufanga recorded 10 tackles and a fumble recovery during the 33–30 overtime victory. During the AFC Championship Game against the Patriots, he had seven tackles and two pass deflections in the 10–7 loss. ==Career statistics==