Shelby County SR 57 starts in Memphis by going south on Trezevant Street from
SR 14 (Jackson Avenue). Trezevant St. turns into East Parkway (at an intersection with
SR 1) and follows
US 70/
US 79/
US 64 and
SR 277. They have an intersection with
Sam Cooper Boulevard before SR 57 turns east and follows
US 72 along Poplar Avenue, where it starts to follow the Norfolk Southern Railway to the north. Poplar Avenue has an interchange with
I-240 in East Memphis and soon enters
Germantown, where it is briefly overlapped with
SR 177. As the road enters
Collierville, it becomes known as West Poplar Avenue (instead of Poplar Avenue). SR 57 meets Byhalia Road (which becomes
Mississippi Highway 309 (MS 309) at the
Mississippi state line) as a crossroads. Just east of that intersection US 72 diverges from SR 57 by going southeast into
Mississippi, via unsigned
SR 86, while SR 57 continues east along West Poplar Ave. SR 57 becomes a two-lane road but remains at a speed until it exits Collierville. East of the Collierville town square, it becomes East Poplar Avenue and
SR 205 (Collierville-Arlington Road) has its southern terminus at SR 57. Poplar Avenue is a major thoroughfare through Shelby County and has much commercial development along its route. In the city of Memphis, the road is locally known for its narrow lanes of traffic and hazardous storm grates along its edges. The many freight trains that run along the side of it cause several traffic delays throughout the day.
Fayette County When SR 57 enters
Fayette County, the speed limit increases to and except for when the road passes through a town, it remains at this speed until it ends in Mississippi. Just outside Collierville, SR 57 has an interchange with
I-269. In the city of
Piperton, SR 57 intersects with
SR 196 and crosses over the Norfolk Southern Railway. A few miles down the road, it passes through
Rossville and is the southern terminus for
SR 194. SR 57 passes over the
Wolf River and passes through
Moscow. The southern terminus of
SR 76 occurs in Moscow. Several miles down the road from here, SR 57 passes through
LaGrange. Motorists can view several of the town's historic buildings from the road. East of LaGrange, SR 57 turns left along
SR 18, passes over the Norfolk Southern Railway again, and then continues east.
Former alignment A former
alignment of SR 57 exists for in
Piperton. The former route exits SR 57 heading south as Commerce Road, and after approximately turns eastward into West Old State Line Road. Old State Line Road then briefly turns into SR 196 before becoming East Old State Line Road. After , East Old State Line Road turns slightly left before reentering SR 57.
Hardeman County After splitting from SR 18, SR 57 enters
Hardeman County and also enters
Grand Junction. It is home to the National Bird Dog Museum, which is visible from the road. SR 57 crosses over the
Mississippi Central Railroad and junctions with
SR 368. Several miles east is the town of
Saulsbury. East of Saulsbury, SR 57 passes over the Norfolk Southern Railway for a third time, and continues east to
Middleton. Here, it intersects with
SR 125 and crosses the
Mississippi Tennessee Railroad. East of Middleton, SR 57 goes through the town of
Pocahontas, where it passes over the Norfolk Southern Railway for the fourth and final time. The railroad continues southeast into Mississippi while SR 57 continues east. It also passes over the
Hatchie River around Pocahontas.
McNairy County SR 57 enters
McNairy County and passes north of
Big Hill Pond State Park. SR 57 passes through Ramer, where it is the northern terminus of
SR 234. It also crosses over the
West Tennessee Railroad (also owned by Norfolk Southern Railway). SR 57 continues east and crosses
US 45 near the town of
Eastview. after crossing US 45, SR 57 goes north of the town of
Michie and intersects with
SR 224. East of Michie, the road junctions with
SR 22, which is the most direct route to
Shiloh National Military Park.
Hardin County SR 57 passes into
Hardin County and intersects with
SR 142 west of the town of
Counce. When SR 57 enters the town of Counce, it crosses a railroad spur of the
Kansas City Southern Railway. East of the town, the road intersects with
SR 128 in
Pickwick Village. SR 128 goes north over
Pickwick Dam, and SR 57 turns right and heads south toward
Pickwick Landing State Park. SR 57 continues south along
Pickwick Lake for approximately until it crosses into Mississippi and becomes
Mississippi Highway 25 (MS 25). ==Major intersections==