After Thihathura died in 1480, the new king
Minkhaung II was greeted by a major rebellion by his brother
Minye Kyawswa, the governor of
Yamethin. In 1482, Thado Minsaw's another elder brother Viceroy
Mingyi Swa of Prome also died. Thado Minsaw took advantage of the war between his nephews Minkhaung II and Minye Kyawswa in Upper Burma by taking over Prome, and declaring himself independent. He raised his brother Mingyi Swa's chief wife
Saw Myat Lay as his chief queen. Minkhaung II managed to send an army to reclaim Prome. But the Avan army could not take Prome, and retreated after a month due to the fierce bombardment from
fire arrows,
cannon, and the newly acquired
muskets. Ava could not send another force again as the much more serious Yamethin rebellion (and rebellions by the Shan States of
Mohnyin and
Kale) consumed its resources for the next two decades. Prome became an independent kingdom with territories that included Tharrawaddy in the south and Myede in the north. Thado Minsaw largely stayed out of the fighting in Upper Burma. He forged a peaceful relationship with
Hanthawaddy, the most powerful kingdom in the region. He changed his policy in the 1520s when Ava was on its last legs suffering from the sustained assaults by
Confederation of Shan States. He entered into a league with
Sawlon, the confederation's leader. On 22 March 1525 (14th waning of Tabaung 886 ME), the combined armies of Confederation and Prome sacked the city of
Ava. The king of Ava,
Shwenankyawshin, who was Thado Minsaw's grandnephew, escaped. Prome and Confederation forces looted the city. The Prome armies brought back the famed poet monk
Shin Maha Rattathara. Prome remained in a league with the Confederation, which continued its attacks on Ava. Thado Minsaw died in February 1527, and was succeeded by his son
Bayin Htwe. ==Family==