The film opens in documentary style, chronicling the work of
Michelangelo Buonarroti. It then follows Michelangelo, a renowned
Cinquecento sculptor of the
Republic of Florence, in the early
16th century, and shows him at work on large-scale sculptures near
St. Peter's Basilica. When
Pope Julius II commissions him to paint the Sistine Chapel, Michelangelo resists because he finds the ceiling's paneled layout of the
Twelve Apostles uninspiring. Nonetheless, he is forced into taking the job. During the initial attempt, Michelangelo is discontented with the results, and destroys the
frescoes. He flees to
Carrara, and then into the mountains where he finds inspiration from nature. Michelangelo returns and is allowed to paint the entire
vault in a variety of newly designed biblical scenes based on the
Book of Genesis, which the Pope approves. The work proceeds nonstop, even with
Mass in session. Michelangelo faces opposition and criticism from the Pope's cardinals, due to its depictons of nudity in the paintings. As months turn to years, Michelangelo's work is threatened when he collapses due to fatigue. He is nursed back to health by
Contessina de' Medici, daughter of his old friend
Lorenzo de' Medici. After recovering, Michelangelo returns to work after learning he is at risk of being replaced by
Raphael, whom the Pope commissions
to paint the reception rooms of
the Papal palace. Meanwhile, the
Papal States are threatened during the
War of the League of Cambrai. Preparing for battle and having reached the limits of his patience, the Pope terminates Michelangelo's contract, and has the scaffolding torn down. Raphael, impressed with the work in progress, asks Michelangelo to show humility and finish the ceiling. Michelangelo travels to see the injured and weakened Pope, and pleads for him to restore the patronage. Though the Pope believes an invasion of Rome is inevitable, he raises the money needed to resume work on the ceiling. One night, Michelangelo finds the ailing Pope inspecting the portrait of
God in
The Creation of Adam, which the Pope declares "a proof of faith" yet doubts Michelangelo's conception of God as merciful and
Adam as innocent, then the Pope collapses and becomes bedridden. Though everyone assumes that the Pope will die, Michelangelo goads him into having the will to live and to finish his work and asks permission to allow him return to Florence, a request the Pope refuses. As Michelangelo leaves, the Pope recovers and upon seeing the cardinals and the monks, as well the choir, he angrily shooes them away. The tide of war turns in favor of the Papal States, as allies (including
England and
Spain) pledge to assist the Pope. A Mass is held in which the congregation is shown the completed ceiling, to a positive response. After the ceremony, Michelangelo asks to begin carving
the Pope's tomb. Realizing he has a short time to live, the Pope agrees but changes his mind when he gives Michelangelo another commission to paint a new fresco behind the altarpiece to replace the dilapidated ones (and gives Michelangelo the choice of subject like the
crucifixion or the
last judgment). The Pope then admits that Michelangelo's conception of God is accurate before goading him to continue his work. As the Pope leaves, Michelangelo turns back to look at the space behind the altarpiece, where he will later paint his
Last Judgement 25 years later. ==Cast==