Kumail and Emily hook up after a comedy show in
Chicago, where Kumail performs
stand-up. Emily, a graduate student from
North Carolina at the
University of Chicago, claims to not want a relationship, but starts dating Kumail soon afterwards. Emily is
White, while Kumail is the son of
Pakistani-American immigrants who want him to quit comedy, pursue a career in law and marry a Pakistani woman. Kumail lies to them about preparing for law exams, and to appease them, occasionally meets women of their choice in an
arranged marriage setup. One afternoon, Emily discovers the headshots of the Pakistani women Kumail has met, leading to an argument. They clash over cultural differences and their views on marriage, and Emily breaks up with Kumail. To move on from Emily, Kumail focuses on stand-up. His improved set brings him better audience reactions and an audition for the
Montreal Comedy Festival. One evening, he learns that Emily has been admitted to a local hospital. When he goes to check on her, he is pulled aside by doctors, who pressure him to sign a medical release to place Emily in an
artificial coma, believing him to be her husband. The doctors later explain to Emily's parents, Terry and Beth, that they are struggling to diagnose her. Kumail's visits to Emily at the hospital endear him to Terry and Beth. Meanwhile, despite undergoing surgery, Emily's condition does not improve. After missing yet another family engagement, Kumail is confronted at his apartment by his parents. When he confesses that he will neither pursue law nor believes in South Asian customs such as arranged marriages, his parents are scandalized. Later, Kumail flops during his Montreal comedy audition, after failing to crack jokes amidst his emotional turmoil. In the morning, Emily awakes from coma. She is diagnosed with
adult-onset Still’s disease, and will recover fully. Terry and Beth celebrate, but Emily does not want to see Kumail and rejects his idea that they get back together. Feeling dejected, Kumail heeds his friends' advice to move to
New York where he can grow his career. He informs his family about his decision and they bid him farewell, signalling a potential acceptance of his life choices. In New York, Kumail debuts a new set at the local comedy club. While generally well-received, he is
heckled by an audience member who is revealed to be Emily. She smiles at him across the room, and as
end credits roll, it is revealed that Kumail marries Emily after reconciling with his parents. == Cast ==