The Exterminators was the second film director
Riccardo Freda made for Comptoir Français du Film Production (C.F.F.P.). Producer
Robert de Nesle's idea of for the film was to adapt
Gérard de Villiers' popular
S.A.S. novels, but he could not obtain the rights. This led to Freda making the fourth film in the
Coplan series. The Coplan films were based on novels by Belgian writers
Gaston Van den Panhuyse and
Jean Libert. The lead in the film was
Richard Stapley, who spoke positively about working with the director, describing him as "a very good director whom everyone thought should be working on much better things than this lowbudget spy film." The film was filmed on location in
Korem,
Turkey and
Paris between 24 June and 9 August 1965. Two endings for the film were shot, one with Coplan ending up with a girl played by De Nesle's girlfriend at the time. Stapley described her acting in the scene as "so inept that the scene couldn't be used." ==Release==