Main characters •
Gerald Goode (voiced by
Mike Judge) – An administrator at a
community college. He comes from a "long line of over-educated academic
liberals". He rides a bicycle for transportation to protect the environment, and his trademark clothing is a
cycling uniform. He is very fastidious and easily disgusted, both by animals and people. His voice and character traits resemble those of the David Van Driessen character from Mike Judge's earlier series
Beavis and Butt-Head. •
Helen Goode (voiced by
Nancy Carell) – Gerald's wife. A local
activist who has "
daddy issues". She is concerned about her social status among the other eco-conscious people in Greenville, and often tries to impress the wealthy wife of Gerald's boss. •
Ubuntu Goode (voiced by
David Herman) – The Goodes' adopted son, named after
Ubuntu, a concept from African philosophy (mispronounced by the characters as instead of ). The Goodes
adopted him in the name of promoting racial tolerance within the community, but due to their vagueness in filling out the adoption paperwork, the family ended up with a
white South African baby instead of the black infant they wanted, but decided to keep him because it was an interesting challenge to raise a "racist born" white baby as a liberal adult. Ubuntu is often shown conflicted with a seemingly innate desire to go against his parents' lifestyle; however, rather than being an outright rebellion, this seems to reflect the
nature and nurture controversy. He sleeps in
footy pajamas that are decorated with big rig trucks. Despite his seemingly naive and childlike nature, he is really accomplished at both sports and machinery; he is a member of his high school's football team. •
Bliss Goode (voiced by
Linda Cardellini) – Helen and Gerald's biological daughter. One of the characters with a sense of reason, she often disagrees with and mocks her parents' political stances, about which she is usually better-informed. She serves as the show's chief foil by poking holes in Gerald's and Helen's world view. In later episodes, she has tended to agree with her parents, and in some instances has usually helped them to achieve a common goal. •
Che (voiced by
Dee Bradley Baker) – The family's dog, named after the communist revolutionary
Che Guevara. The Goodes feed him vegan food which he dislikes. He craves meat and often eats neighborhood animals and pets. As a consequence, "missing" flyers of neighborhood pets blanket street poles. •
Charlie (voiced by
Brian Doyle-Murray) – Helen's
politically incorrect SUV-driving father who mostly likes making fun of her lifestyle. He frequently ridicules Gerald and Helen for their beliefs, although he seems to favor Ubuntu more due to him being involved in the football team, and Bliss who seems to share his opinions.
Other characters •
Kent Jensen (voiced by
Jonathan Slavin) – Gerald's boss at Greenville Community College, and Margo's husband. •
Kiki (voiced by
Amy Hill) – The Goodes' next-door neighbor, 41 years old. •
Margo Jensen (voiced by
Julia Sweeney) – Helen's arrogant rival who relentlessly puts down the Goodes (but mostly just Helen), 45 years old. She is an influential member of the Greenville community and embodies everything Helen wants to be, while at odds with Helen and vice versa. Helen seems to mostly get the best of her, and her purpose is to show the type of person who is holier-than-thou while being a faux personality who seizes on fads to increase her social standing. •
Penny (voiced by
Masiela Lusha) – A neighbor who is single and childless, and makes occasional comments about her loneliness and desire to have children. Her beliefs fluctuate, and she will take liberal causes only to abandon them shortly afterwards to her personal benefit. •
Ray Johnson (voiced by
Gary Anthony Williams) – An easy-going, country music-loving black neighbor of the Goodes who drives a gas-guzzling car and thinks of race as less important than the Goodes do, as an unexpected device. 43 years old. •
Mo (voiced by
Laraine Newman) – A lesbian the Goodes are friends with, along with her partner, Trish. Mo worked on an oil rig and is 47 years old. •
Solosolo (voiced by
Phil LaMarr) – Football quarterback at Greenville High School, and son of Kiki, 17 years old. •
Souki (voiced by
Cree Summer) – A lesbian, 40 years old. •
Jenn (voiced by
Grey DeLisle) – Another lesbian, and Souki's partner. 41 years old. •
Treyvon (voiced by David Herman) – A teenage employee at
One Earth, an
organic supermarket frequented by the Goodes, Margo and Greenville's Liberal elite (the store is frequently seen featuring a large sign telling its shoppers what is good and what is bad;
Farm-Raised Catfish constantly moving between good and bad). Treyvon is also an amateur filmmaker whom Bliss tries to befriend. He comes across as a suburbanite that thinks it is "cool" to make fun of others with illiberal beliefs. •
Mr. Heelo (voiced by
Howard Kremer) – The manager of the "One Earth" supermarket, 38 years old. •
Trish (voiced by Julia Sweeney) – Trish is Mo's partner. •
The Average Guy (voiced by Mike Judge or David Herman) - A newscaster that does stories from the average point of view. •
Maffew (voiced by Phil LaMarr) – Leader of a gang of thugs. •
Dawn (voiced by
Tara Strong) – Female member of Maffew's gang, 16 years old. •
Other Two Thugs (voiced by Phil LaMarr and David Herman) – Members of Maffew's gang. •
Principal Whitmore (voiced by Phil LaMarr) – Principal at Greenville Community College. •
Mrs. Glavin (voiced by Tara Strong) – Teacher at Greenville Community College. •
Tanya (voiced by
Cree Summer) – Greenville Community College student who is in model congress. •
Isabelle (voiced by Laraine Newman) – Duncan's wife. •
Professor Mead (voiced by
Elvis Costello) – Teacher at
Oxford University, 45 years old. •
Michelle (voiced by
Alyson Hannigan) – Director of community service at Greeneville Community College, 25 years old. •
Jeff (voiced by
Diedrich Bader) – Teacher at Greenville Community College. •
Duncan (voiced by Gary Anthony Williams) – Isabelle's husband. •
Benny (voiced by David Herman) – Victim of the rival drug dealers. ==Crew==