Doyle was selected by the
Buffalo Bills in the fifth round (161st overall) of the
2021 NFL draft. The Bills previously acquired the pick in a trade with the
Las Vegas Raiders that sent
Zay Jones to the Raiders. On May 13, 2021, Doyle signed his four-year rookie contract with Buffalo. On January 15, 2022, Doyle scored his first NFL touchdown, catching a one-yard pass from
Josh Allen in the Bills' 47–17 win over the
New England Patriots in the Wild Card round of the
2021–22 NFL playoffs. On September 27, 2022, Doyle was placed on season-ending injured reserve after suffering a torn
ACL against the
Miami Dolphins in Week 3. On August 21, 2023, Doyle was placed on injured reserve after suffering a knee injury in the preseason. It was also revealed that his left leg was diagnosed with nerve damage. On June 4, 2024, the Bills placed Doyle on the reserve/PUP list. He did not play for the entire 2024 season. On February 14, 2025, Doyle announced his retirement from professional football due to medical reasons. He had not appeared in a regular season game since Week 3 of the 2022 season. However, Doyle was eligible for an NFL pension, since seasons on Injured Reserve or the PUP list counted towards the three seasons required to be eligible. ==References==