Main •
Nicholas D'Agosto as Josh Segal, a defense lawyer from New York who finds his first experience of murder trials in East Peck, South Carolina. He has to put up with the antics of his team members much to his chagrin. He becomes involved in a love triangle between Carol Anne and Nina during Season 2. •
Jayma Mays as Carol Anne Keane, Assistant District Attorney of East Peck and Josh's rival as well as love interest. She becomes pregnant in Season 2, expecting a baby by an unknown father. •
Steven Boyer as Dwayne Reed, Josh's lead investigator and a former police officer in East Peck. He rejoins the police force in Season 2, while simultaneously working for the defense team. •
Sherri Shepherd as Anne Flatch, the daughter of Larry Henderson who later joins Josh's team. Like Josh, she is serious and the least nonsensical of the group. •
John Lithgow as Larry Henderson (season 1), a poetry professor and the suspect on trial for the murder of his wife. •
Amanda Payton as Nina Rudolph (season 2), a stylish podcast host who moves to East Peck from New York to follow the trial of Lavinia Peck Foster and ends up tangled in a love triangle. •
Kristin Chenoweth as Lavinia Peck-Foster (season 2), an eccentric heiress of East Peck. She hires Josh and his associates after finding her husband stuffed in a suitcase in the back of her car.
Recurring •
Bob Gunton as Jeremiah Jefferson Davis, a tobacco businessman, Margaret's brother, and hence Larry's brother-in-law. •
Cristine Rose as Josie Jefferson Davis, the quiet, alcoholic wife of Jeremiah and the sister-in-law of Larry and Margaret Henderson. •
Angel Parker as Heidi Baker, a local TV journalist who reports on the investigation of Larry Henderson. •
Dave Allen as Dave, a
taxidermist who owns a shop next to Josh's office. •
Kevin Daniels as Alfonzo Prefontaine, Larry's fitness trainer and lover. •
Patricia Belcher as E. Horsedich (pronounced
Hi-sen-dich, with a soft "c" on the last syllable), the judge who presides over the case of
People v. Larry Henderson. •
Kevin Durand as Rutger Hiss, a local police officer who leads the investigation of Larry Henderson. Despite his comatose state, he is elected mayor of East Peck in Season 2. •
Julie Hagerty as Madame Rhonda, a
pet psychic who later becomes Juror 9 in the trial of
People v. Larry Henderson. •
Michael Hitchcock as Jesse Ray Beaumont (season 2), a horologist that was tried and convicted for the murder of Lavinia's brother Chet nine years ago. • Joel McCrary as Alexander Kamiltow (season 2), the judge for Lavinia's trial. Unlike Horsedich, his name is pronounced the way it is spelled. After trying to stop a chaotic outburst in Jesse Ray Beaumont's trial, he lost his voice, and now speaks in unintelligible gibberish, yet everyone but Josh understands him perfectly. •
Shannon Chan-Kent as Clem Tuckett (season 2), an anchorwoman covering the investigation of Lavinia Peck-Foster. •
Serge Houde as Milton The Houseboy (season 2), Lavinia's loyal manservant and long-suffering confidante. •
Jaleel White as Atticus Ditto, Jr. (season 2), the prosecutor who took over Beaumont's first Trial when Carol Anne was removed, and Carol Anne's rival for the D.A. election. •
Andy Thompson as Dr Rock n' Law (season 2), Beaumont's defense attorney in his original trial, and aspiring rock musician.
Guest •
Andrew Daly as Thom Hinkle, a DNA expert who suffers from a bizarre type of
OCD. It is revealed in season 2 that he is now decommissioned because of his bizarre OCD. •
Marla Gibbs as Mrs. Kratt, Larry's antipathetic neighbor. •
Fred Melamed as Howard Mankiewicz, a founding partner of the firm where Josh works. •
Andie MacDowell as Margaret Henderson, Larry's deceased wife whose murder becomes the subject of the first season of the mockumentary. •
Adam Campbell as Dr. Shinewell, veterinarian/OBGYN for East Peck ==Episodes==