On January 19, 2021 it was announced that Isley had signed a promotional contract with
Top Rank where he would be promoted by
Bob Arum. Isley made his professional debut on February 13, scoring a
unanimous decision (UD) victory against Bryant Costello. On January 15, 2022 Isley faced Harry Keenan Cruz Cubano on the
undercard of
Joe Smith Jr. vs Steve Geffrard at the
Turning Stone Resort Casino in
Verona, New York. In a bout which saw Isley receive a point deduction in round six for repeated low blows, he went on win via UD with two judges scoring the bout 59–54 and the third scoring it 59–53. On March 2, 2024 Isley defeated Marcos Hernandez by TKO in the seventh round in Verona, New York. Isley defeated old amateur rival
Javier Martínez at
Fontainebleau Las Vegas on June 21, 2024. Isley is scheduled to face Tyler Howard in a 10-round middleweight bout on November 8, 2024 in Norfolk, VA. ==Professional boxing record==