Madrimov vs. Hernandez Madrimov made his professional debut on 24 November 2018, against Vladimir Hernandez at the
Hard Rock Live in
Atlantic City, New Jersey, with the vacant
WBA Inter-Continental
light-middleweight title on the line. Madrimov dropped his opponent in round three en route to a sixth-round
technical knockout (TKO) victory. At the time of the stoppage, Madrimov was ahead on all three judges' scorecards (50–44, 50–43, 49–45). The fight was part of the undercard for
Dmitry Bivol's successful world title defence against
Jean Pascal.
Madrimov vs. Rojas Madrimov made the first defence of his title, again on the undercard of a Dmitry Bivol world title fight – this time against
Joe Smith Jr. – on 9 March 2019 against Frank Rojas at the
Turning Stone Resort & Casino in
Verona, New York. Madrimov dropped his opponent in round two with a left hook. Rojas rose to his feet before the referee's count of ten, only to be knocked unconscious moments later with another powerful left hook, giving Madrimov the win via second-round
knockout (KO). Two days before the fight it was announced Madrimov's promoters, World of Boxing, had signed a co-promotional deal with
Eddie Hearn's
Matchroom Boxing USA.
Madrimov vs. Gonzalez Madrimov won via sixth-round technical knockout over Norberto Gonzalez at
Madison Square Garden in
New York City, New York, USA on 8 June 2019.
Madrimov vs. Barrera Madrimov defended his title for a second time against
Alejandro Barrera on 5 October 2019 at
Madison Square Garden,
New York City, on the undercard of the
Gennady Golovkin vs.
Sergiy Derevyanchenko world title fight. Madrimov retained his title with a fifth-round TKO.
Madrimov vs. Walker On 15 August 2020, Madrimov fought Eric Walker in the co-main event on a
DAZN-televised card in
Tulsa, Oklahoma. Madrimov won the fight by unanimous decision. However, there was controversy, as it appeared that Madrimov had knocked Walker down and out with a legal punch in the ninth round of the fight, but referee Gary Ritter ruled that it was not a knockdown or a knockout, but rather that Madrimov had illegally knocked Walker down with his shoulder. As Walker remained down on the canvas for a minute, telling Ritter that he was dizzy, Ritter implored the fighter to get back up. After a minute, Walker stood up, stumbled into the ropes and then collapsed into the corner. Ritter gave Walker five minutes to recover and then restarted the fight, allowing Walker to take further punishment for 2+ rounds. Hall-of-Fame referee
Steve Smoger admonished Ritter after the fight for not ruling a knockdown and subsequent knockout, asserting that Walker took unnecessary punishment as a result.
Madrimov vs. Soro On 17 December 2021, Madrimov fought
Michel Soro, who was ranked #1 by the WBA at light middleweight, in an eliminator for the
WBA light-middleweight championship. Madrimov won by technical knockout in the ninth round.
Madrimov vs. Soro II The next bout was a rematch against Soro. A violent clash of heads in the third round cut Soro near the left eye and blood poured on the canvas. After consultation, referee Steve Gray decided to stop the bout and the bout ended in a technical draw.
Madrimov vs. Kurbanov On March 8, 2024 in
Riyadh, Saudi Arabia, Madrimov faced the undefeated Magomed Kurbanov for the vacant WBA light-middleweight title. He stopped Kurbanov in the fifth round, winning the title. In
Tashkent, Israil Madrimov was awarded by the President of the Republic of Uzbekistan. He was handed the keys to a Chevrolet Tahoe.
Madrimov vs. Crawford On April 20, 2024, it was reported that Madrimov would make the first defense of his WBA light-middleweight title against
ESPN's #1 P4P fighter
Terence Crawford on August 3, 2024, at
BMO Stadium in
Los Angeles,
California, with the vacant
interim WBO title also on the line. Crawford, undefeated at 40–0 and a two-time
undisputed champion and
three-weight world champion, was coming off of a stoppage victory over
Errol Spence Jr. to become undisputed at
welterweight. Madrimov proved to be a difficult matchup for Crawford, preventing Crawford from settling into his rhythm and repeatedly catching him with a straight rights, while Crawford found success behind the southpaw jab, landing with hard uppercuts and being more active. Despite a constant back-and-forth, Crawford edged out a unanimous decision victory, handing Madrimov his first loss and ending his brief title reign. Madrimov nevertheless became the first person to go the distance with Crawford since 2016 after an 11-fight stoppage streak, and the competitiveness of the bout even made some observers question Crawford's ability at heavier weights.
Madrimov vs. Ortiz Following his loss to Crawford, Madrimov was initially scheduled to next face
Serhii Bohachuk on the
Oleksandr Usyk vs. Tyson Fury 2 undercard at the
Kingdom Arena in Riyadh,
Saudi Arabia, on December 21, 2024. However, Madrimov pulled out citing bronchitis and was replaced by Ishmael Davis. Instead, Madrimov's next fight would be against
Vergil Ortiz Jr. on the undercard of
Beterbiev vs. Bivol 2 on February 22, 2025, this time at The Venue Riyadh Season in Riyadh. This fight would be for Ortiz's
WBC interim light-middleweight title. After 12 rounds, Madrimov lost by unanimous decision, with two scores of 115–113 and one score of 117–111. Madrimov was the second fighter to go the distance with Ortiz, following Bohachuk in his previous fight.
Madrimov vs. Salazar After 11 months out of the ring due to knee and shoulder surgeries, Madrimov faced Luis David Salazar on 24 January 2026 at
Fontainebleau in
Las Vegas, USA. Madrimov had also been recovering from pneumonia prior to the bout. He won by unanimous decision, earning scores of 99–1 from all three judges. Though Madrimov suffered significant swelling over the left eye, he remained undeterred and controlled the bout from start to finish, hurting Salazar in the final round. ==Professional boxing record==