Pierce made his television debut on the
HBO anthology series
Vietnam War Story in the third episode, "The Pass", along with
Ching Valdes-Aran,
Tony Becker, and
Merritt Butrick. His second television role was
Dr. Wolff in two episodes of
The Equalizer (1988, 1989). Pierce worked on the HBO dramas
The Wire and
Treme. When first cast in
The Wire, he and his castmates doubted the show would be a hit: "I remember the first time we all sat around and watched the pilot. We all turned to each other and said, 'Man, I don't think this shit is going anywhere.'" In 2012, he played
J. Jenks in
The Twilight Saga: Breaking Dawn – Part 2. Pierce was nominated for an
Independent Spirit Award for Best Male Lead for his portrayal of Joe, a married and closeted gay man who steps out on his family with a young white man he met online, in
Four. The film was released in September 2013, around the same time that
The Michael J. Fox Show debuted on
NBC, in which Pierce played
Michael J. Fox's character's boss. The show was canceled five months later. Pierce wrote and published a book in 2015,
The Wind in the Reeds: A Storm, A Play, and the City That Would Not Be Broken on his experiences with the Beckett play
Waiting for Godot, and the flooding of New Orleans in 2005. From 2015 to 2017, Pierce starred alongside
Matthew Perry and
Thomas Lennon in
CBS's revival of the sitcom
The Odd Couple, playing the role of Teddy. When
Mike Henry stepped down as the voice of
Cleveland Brown on
Family Guy in June 2020, in light of the
George Floyd protests, Pierce launched a campaign to become Henry's replacement. He lost the role to YouTube personality
Arif Zahir.
Stage Pierce has been in numerous stage productions. He was lauded for his performance as Holt Fay in
Queenie at the
John F. Kennedy Center. He has performed
on Broadway in staged productions of
The Piano Lesson,
Serious Money, and
The Boys of Winter. He has performed
off-Broadway in
The Cherry Orchard (for which he was nominated for a
VIV Award for Lead Actor),
Waiting for Godot (which was set on a New Orleans rooftop post-Hurricane Katrina), and
Broke-ology performed at
Lincoln Center for the Performing Arts. Other performances include
Cymbeline (at
The Public Theater),
The Good Times Are Killing Me,
Two Gentlemen of Verona, ''
Tis Pity She's a Whore, and Ms. Ever's Boys'' performed at the
ACT Theatre. Pierce is also a theater producer, and produced the Broadway show
Clybourne Park. The show was nominated for four
Tony Awards and won the
Tony Award for Best Play in 2012. In 2015, Pierce returned to the stage to star in the
Billie Holiday Theatre production of Jackie Alexander's
Brothers from the Bottom in New York. In 2019, Pierce starred in the acclaimed
Arthur Miller play
Death of a Salesman at the
Young Vic Theatre in
London and its successful transfer to the West End. For this performance, he received a nomination for the
Olivier Award for Best Actor. The show made its
Broadway transfer in 2022, returning with Pierce,
Sharon D. Clarke, and
Andre De Shields. In December 2022, on one of the nights of its production run, a woman disrupted the beginning of Act 2, shouting at the stage. Pierce tried to calm her down from the stage. She was eventually escorted out of the building by authorities and the play's producers issued a statement saying, "We're grateful to the entire team at the
Hudson Theatre for working together to resolve the situation and resume the performance as quickly as possible." Videos of the event and Pierce's attempts to reason with the patron went viral online. Pierce received a 2023
Tony Award nomination for the production.
Radio In 2009, Pierce became the host of the nationally syndicated,
Peabody Award-winning radio program
Jazz at Lincoln Center, which featured live recordings from
Jazz at Lincoln Center's House of Swing.
Music In 2016, Pierce started appearing on several albums recorded in New Orleans. He recorded the song "Make America Great Again" with
Delfeayo Marsalis in 2016, one song with
Kermit Ruffins on
Irvin Mayfield's 2017 album
A Beautiful World, and one with
Stanton Moore on his 2017 album
With You In Mind. In 2020, Pierce recorded "The Ever Fonky Lowdown" with
Wynton Marsalis. ==Business and philanthropy==