• Kelsy Abbott as Reggie, Wade, Kathy, Flaps, Flowery Woman, Billy Canyon, Tammy, Dr. Tenders, Swimple Jan, Plates, Mike, Omelet, Winged Moyse • Antony Del Rio as Todd, Chairold, Garrett, Sherbert •
Jaylen Barron as Esther, Pretty Please, Tater Tot, Gorbis, Darla, Tori •
Matt Berry as The Butt Witch •
Steve Agee as Big Deal, Mack, Beefhouse, Galaxander, Hunk, Monster Brown Roger • Wade Randolph as Borbo, Dr. Champion, Mr. Christopherson, Label Maker Monster, Lump, Uncle Paul, AJ, Bobby • Laura Zak as Mrs. Krandle, Tanopy, Explorer Sally, Pancake, Rooty, Lorbis, Queen Limerick •
Bridget Everett as Judy • Spencer Rothbell as Colin, Swimple Dan, Tasty Troy, Pitui-Terry, Squad Bro, Rance, Big Ol' Gordon, Jacques Board, Shaun • Nick Sumida as Bags of Marbles, Beth, Chewing Gum Stanley, Garrett, Señor Corduroy •
Brandon Wardell as Dustin • Daniel Amerman as Aaron •
Sam Brown as Manny, Schmaaron •
Noel Fielding as Guy Pleasant • Kate Freund as Donna • John Eric Bentley as Mr. Kapusinski •
Ron Funches as Manguin •
Brittany Ashley as Kendra, Leslie •
Amy Sedaris as Sadmantha • Maximus Riegel as Ogden •
Stephanie Beatriz as Conelly •
Chris Fleming as Mr. Fleming •
Ashley Boettcher as Gwen • Curt Neill as Rodney •
Paul Williams as Captain Elmer • Reese Hartwig as Shane (pilot only) •
Jorge Diaz as Tristan (pilot only) ==Production==