Before the U.S. Route system was established in 1926, the road that became US 25 was mostly numbered as State Route 6 (SR 6), but was numbered as
SR 28 and SR 124 in the Cincinnati area. The route that became US 25 was also part of the eastern leg of the
Dixie Highway. In 1950s and 1960s, US 25 was transferred to a new freeway that was the basis for
I-75. Nearly all of the original road remains intact, however, still named Dixie Highway in some parts, and with some segments given
county highway designations of CR-25A. In 1973, the route was
decommissioned in Ohio and Michigan due to its redundancy with Interstate highways. From Cygnet northward, the independent routing of US 25, up to its concurrency with
US 24 at the intersection of Detroit Avenue and Cherry Street, became the whole of
SR 25. The former concurrency to Telegraph Road retained the US 24 designation, while the remaining segment of Detroit Avenue northward to the state line was decommissioned as a state highway, continuing into Michigan as
M-125/Dixie Highway. In 1986, the segment of SR 25 along Detroit Avenue was swapped with US 24, with the state route taking a new alignment from downtown Toledo to
I-280. ==Major intersections==