Ohio US 322 begins at the intersection of Superior Avenue and East Roadway at
Public Square in
Downtown Cleveland, just northeast of the junction of U.S. Routes
US 6,
US 42, and
State Route 3 (Superior Avenue) with
US 422 and
State Route 8,
State Route 14,
State Route 43, and
State Route 87 (Ontario Street). East of Public Square, the route runs eastward through midtown Cleveland conjoined with US 6 along Superior Avenue. Northwest of
Cleveland State University, US 322 turns south onto 13th Street and runs eastward (as Chester Avenue) through
Playhouse Square. Exiting the commercial district, US 322 interchanges
Interstate 90, at exit 173. In
University Circle, US 322 is briefly concurrent with
U.S. Route 20 (
Euclid Avenue), running through the campus of
Case Western Reserve University. The overlap terminates at the eastern edge of University Circle, where US 322 splits off to the south by southwest, becoming Mayfield Road as it enters
Little Italy, and through the eastern
suburbs of
Cleveland Heights,
South Euclid,
Lyndhurst,
Mayfield Heights, and
Gates Mills, continuing on as Mayfield until the
Geauga County/
Ashtabula County line. In Geauga County, US 322 passes through suburban
Chester Township and into Ohio's second largest
Amish community, which includes the rural townships of
Claridon,
Huntsburg,
Windsor Township and the west side of Orwell Township. In Ashtabula County, US 322 crosses through
Windsor Township, Orwell Township, the village of
Orwell, Colebrook Township, Wayne Township and
Williamsfield Township before crossing the Ohio-Pennsylvania state line south of
Pymatuning Reservoir.
Pennsylvania US 322 enters
Pennsylvania from Ohio in
West Shenango Township. From this point, the road continues east, forming a concurrency with
U.S. Route 6 between
Conneaut Lake and
Meadville, interchanging with
Interstate 79 and intersecting
U.S. Route 19 in Meadville. In
Franklin, the route crosses
U.S. Route 62. Continuing east, US 322 interchanges with
Interstate 80 near
Clarion before meeting
U.S. Route 119 and
U.S. Route 219 south of
DuBois. US 322 heads southeast as a surface road before merging onto the
Interstate 99/
U.S. Route 220 freeway in
Port Matilda, following that east to
State College. The US 322 freeway continues past I-99 before ending to the east of State College. Near
Potters Mills, US 322 becomes a freeway again and intersects
U.S. Route 22 and
U.S. Route 522 in
Lewistown, forming a long concurrency with the former.
New Jersey on the
Commodore Barry Bridge. US 322 enters New Jersey via the
Commodore Barry Bridge just north of
Delaware and interchanges with
Interstate 295 and the
New Jersey Turnpike before entering historic
Mullica Hill. In
Glassboro, it bisects
Rowan University. At
Williamstown, US 322 goes onto the
Black Horse Pike (picking up where
Route 42 ends) and follows it the rest of the way to Atlantic City, being concurrent with
U.S. Route 40 from
Mays Landing on east. In the 1960s and 1970s, the
New Jersey Department of Transportation (NJDOT) had planned for a freeway bypass of U.S. Route 322 around Glassboro. Later it was planned as a New Jersey Turnpike extension, but all plans were dropped due to budget cuts and mounting opposition. ==Major intersections==